Phase II trial of cisplatin and α-interferon in advanced malignant melanoma

Kim A. Margolin, James H. Doroshow, Steven A. Akman, Lucille A. Leong, Robert J. Morgan, George Somlo, James Raschko, Cynthia Pereira, Lisa Yonemoto, Chul Ahn

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30 Scopus citations

Abstract

Purpose: To evaluate the antitumor activity of combination cisplatin (CDDP) and α-interferon (α-IFN) in advanced, measurable metastatic melanoma. Patients and Methods: Adult patients with metastatic melanoma were required to have bidimensionally measurable lesions and a Karnofsky performance status ≥ 60%. Serum creatinine ≤ 1.5 mg/dL, creatinine clearance ≥ 60 mL/min, adequate organ and bone marrow function, and radiologic proof of the absence of brain metastases were required. CDDP 40 mg/m2 intravenously (IV) on day 1 and day 8, and α-IFN 3 million units/m2 subcutaneously on days 1 to 5 and 8 to 12 were administered every 3 to 4 weeks. Results: Forty-two patients were entered onto this phase II trial and were assessable for response and toxicity. Three patients achieved complete responses (CRs) that lasted 31+, 5, and 8+ months. Seven patients had partial responses (PRs) and a median response duration of 4.4 months. The overall objective response rate was 24% (95% confidence interval, 12% to 39%). Toxicities were mild. Only 11% of the courses required dose reduction of α- IFN, and three of 128 courses required CDDP dose reduction for reversible nephrotoxicity. Conclusion: The combination of moderate-dose CDDP and α-IFN as administered in this schedule is well tolerated and possesses encouraging activity in metastatic melanoma.

Original languageEnglish (US)
Pages (from-to)1574-1578
Number of pages5
JournalJournal of Clinical Oncology
Volume10
Issue number10
DOIs
StatePublished - Jan 1 1992

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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    Margolin, K. A., Doroshow, J. H., Akman, S. A., Leong, L. A., Morgan, R. J., Somlo, G., Raschko, J., Pereira, C., Yonemoto, L., & Ahn, C. (1992). Phase II trial of cisplatin and α-interferon in advanced malignant melanoma. Journal of Clinical Oncology, 10(10), 1574-1578. https://doi.org/10.1200/JCO.1992.10.10.1574