Phase II trial of oral etoposide plus cisplatin in extensive stage small cell carcinoma of the lung: an Eastern Cooperative Oncology Group study

Joan H. Schiller, David S. Ettinger, Marilyn M. Larson, William Gradishar, Douglas Merkel, David H. Johnson

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Based upon the schedule specificity of etoposide and the in vitro and clinical synergy sbserved with cisplatin, the Eastern Cooperative Oncology Group conducted a phase II trial of oral etoposide and cisplatin in newly diagnosed, untreated patients with extensive stage small cell carcinoma of the lung. 35 patients received 100 mg/m2 of cisplatin intravenously on day 1 and 50 mg/m2 of etoposide orally for 21 consecutive days. Cycles were repeated every 28 days. The most common toxicity observed was myelosuppression. Sixty-seven per cent of patients had grade 3 or 4 leukopenia and 34% had grade 3 or 4 thrombocytopenia during cycle one. Of 26 evaluable patients, 4 had a complete response (15%) and 17 had a partial response (65%). The median survival for the group as a whole was 8.5 months. We conclude that this regimen was associated with significant myelosuppression, and offered no therapeutic advantage to other commonly administered chemotherapeutic regimens for small cell carcinoma of the lung.

Original languageEnglish (US)
Pages (from-to)158-161
Number of pages4
JournalEuropean Journal of Cancer
Volume30
Issue number2
DOIs
StatePublished - 1994

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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