Phase-resetting sensitivity of the suprachiasmatic nucleus and oscillator amplitude: Reply to letter by Ruby

Ethan D. Buhr, Seung Hee Yoo, Joseph S. Takahashi

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The amplitude of a circadian oscillator influences its response to a phase-resetting stimulus. The suprachiasmatic nucleus (SCN) is unique among circadian clocks in mammals in that the network connections among its neurons confer robustness both in amplitude and in resilience to perturbations. With reduced coupling among SCN neurons, the SCN becomes more susceptible to external phase-shifting stimuli. Thus, stimuli of the same strength will elicit different responses from the same tissue under different states of internal coupling. In his letter, Ruby (2011 [this issue]) discusses potential causes for discrepancies in studies that report dissimilar responses of the SCN to temperature changes. Here, we propose that the differences are likely due to a species difference and a difference in oscillator amplitude. These differences more likely result from inherent differences between mice and rats than from experimental procedures.

Original languageEnglish (US)
Pages (from-to)371-373
Number of pages3
JournalJournal of Biological Rhythms
Volume26
Issue number4
DOIs
StatePublished - Aug 2011

Fingerprint

Suprachiasmatic Nucleus
Neurons
Circadian Clocks
Mammals
Temperature

Keywords

  • circadian
  • methods
  • suprachiasmatic
  • temperature

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

Cite this

Phase-resetting sensitivity of the suprachiasmatic nucleus and oscillator amplitude : Reply to letter by Ruby. / Buhr, Ethan D.; Yoo, Seung Hee; Takahashi, Joseph S.

In: Journal of Biological Rhythms, Vol. 26, No. 4, 08.2011, p. 371-373.

Research output: Contribution to journalArticle

@article{ac188dee5a1b44118d89a3265f98f4d8,
title = "Phase-resetting sensitivity of the suprachiasmatic nucleus and oscillator amplitude: Reply to letter by Ruby",
abstract = "The amplitude of a circadian oscillator influences its response to a phase-resetting stimulus. The suprachiasmatic nucleus (SCN) is unique among circadian clocks in mammals in that the network connections among its neurons confer robustness both in amplitude and in resilience to perturbations. With reduced coupling among SCN neurons, the SCN becomes more susceptible to external phase-shifting stimuli. Thus, stimuli of the same strength will elicit different responses from the same tissue under different states of internal coupling. In his letter, Ruby (2011 [this issue]) discusses potential causes for discrepancies in studies that report dissimilar responses of the SCN to temperature changes. Here, we propose that the differences are likely due to a species difference and a difference in oscillator amplitude. These differences more likely result from inherent differences between mice and rats than from experimental procedures.",
keywords = "circadian, methods, suprachiasmatic, temperature",
author = "Buhr, {Ethan D.} and Yoo, {Seung Hee} and Takahashi, {Joseph S.}",
year = "2011",
month = "8",
doi = "10.1177/0748730411411679",
language = "English (US)",
volume = "26",
pages = "371--373",
journal = "Journal of Biological Rhythms",
issn = "0748-7304",
publisher = "SAGE Publications Inc.",
number = "4",

}

TY - JOUR

T1 - Phase-resetting sensitivity of the suprachiasmatic nucleus and oscillator amplitude

T2 - Reply to letter by Ruby

AU - Buhr, Ethan D.

AU - Yoo, Seung Hee

AU - Takahashi, Joseph S.

PY - 2011/8

Y1 - 2011/8

N2 - The amplitude of a circadian oscillator influences its response to a phase-resetting stimulus. The suprachiasmatic nucleus (SCN) is unique among circadian clocks in mammals in that the network connections among its neurons confer robustness both in amplitude and in resilience to perturbations. With reduced coupling among SCN neurons, the SCN becomes more susceptible to external phase-shifting stimuli. Thus, stimuli of the same strength will elicit different responses from the same tissue under different states of internal coupling. In his letter, Ruby (2011 [this issue]) discusses potential causes for discrepancies in studies that report dissimilar responses of the SCN to temperature changes. Here, we propose that the differences are likely due to a species difference and a difference in oscillator amplitude. These differences more likely result from inherent differences between mice and rats than from experimental procedures.

AB - The amplitude of a circadian oscillator influences its response to a phase-resetting stimulus. The suprachiasmatic nucleus (SCN) is unique among circadian clocks in mammals in that the network connections among its neurons confer robustness both in amplitude and in resilience to perturbations. With reduced coupling among SCN neurons, the SCN becomes more susceptible to external phase-shifting stimuli. Thus, stimuli of the same strength will elicit different responses from the same tissue under different states of internal coupling. In his letter, Ruby (2011 [this issue]) discusses potential causes for discrepancies in studies that report dissimilar responses of the SCN to temperature changes. Here, we propose that the differences are likely due to a species difference and a difference in oscillator amplitude. These differences more likely result from inherent differences between mice and rats than from experimental procedures.

KW - circadian

KW - methods

KW - suprachiasmatic

KW - temperature

UR - http://www.scopus.com/inward/record.url?scp=79960713148&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79960713148&partnerID=8YFLogxK

U2 - 10.1177/0748730411411679

DO - 10.1177/0748730411411679

M3 - Article

AN - SCOPUS:79960713148

VL - 26

SP - 371

EP - 373

JO - Journal of Biological Rhythms

JF - Journal of Biological Rhythms

SN - 0748-7304

IS - 4

ER -