Lithiomethyl and toluene-4-sulphonyl(potassiomethyl)isonitriles have been applied in short high-yield homologations of O-benzylvanillin, O-benzylisovanillin, and veratraldehyde giving N-(2-arylethyl)-2-arylacetamides and subsequently isoquinoline derivatives. These experiments are relevant to the preparation of alkaloids including papaverine and reticuline.
|Original language||English (US)|
|Number of pages||10|
|Journal||Journal of the Chemical Society, Perkin Transactions 1|
|State||Published - Dec 1 1979|
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