Phenotype and genotype of pancreatic cancer cell lines

Emily L. Deer, Jessica González-Hernández, Jill D. Coursen, Jill E. Shea, Josephat Ngatia, Courtney L. Scaife, Matthew A. Firpo, Sean J. Mulvihill

Research output: Contribution to journalReview article

421 Scopus citations

Abstract

The dismal prognosis of pancreatic adenocarcinoma is due in part to a lack of molecular information regarding disease development. Established cell lines remain a useful tool for investigating these molecular events. Here we present a review of available information on commonly used pancreatic adenocarcinoma cell lines as a resource to help investigators select the cell lines most appropriate for their particular research needs. Information on clinical history; in vitro and in vivo growth characteristics; phenotypic characteristics, such as adhesion, invasion, migration, and tumorigenesis; and genotypic status of commonly altered genes (KRAS, p53, p16, and SMAD4) was evaluated. Identification of both consensus and discrepant information in the literature suggests careful evaluation before selection of cell lines and attention be given to cell line authentication.

Original languageEnglish (US)
Pages (from-to)425-435
Number of pages11
JournalPancreas
Volume39
Issue number4
DOIs
StatePublished - May 1 2010

Keywords

  • Adhesion
  • Angiogenic potential
  • Invasion
  • Migration
  • Pancreatic adenocarcinoma cell lines
  • Tumorigenicity

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Hepatology
  • Endocrinology

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  • Cite this

    Deer, E. L., González-Hernández, J., Coursen, J. D., Shea, J. E., Ngatia, J., Scaife, C. L., Firpo, M. A., & Mulvihill, S. J. (2010). Phenotype and genotype of pancreatic cancer cell lines. Pancreas, 39(4), 425-435. https://doi.org/10.1097/MPA.0b013e3181c15963