Phenotypic and functional consequences of herpesvirus saimiri infection of human CD8+ cytotoxic T lymphocytes

Keith R. Berend; Jae U. Jung; Terence J. Boyle; J. Michael DiMaio; Salvatore A. Mungal; Ronald C. Desrosiers; H. Kim Lyerly

Phenotypic and functional consequences of herpesvirus saimiri infection of human CD8⁺ cytotoxic T lymphocytes

Keith R. Berend, Jae U. Jung, Terence J. Boyle, J. Michael DiMaio, Salvatore A. Mungal, Ronald C. Desrosiers, H. Kim Lyerly

Cardio Thoracic Surgery

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37 Scopus citations

Abstract

Herpesvirus saimiri (HVS) was used to infect and transform human CD8⁺ cytotoxic T lymphocytes (CTL), and the phenotypic and functional consequences of HVS infection of CD8⁺ T lymphocytes were investigated. HVS-transformed CTL no longer require antigen restimulation yet maintain their phenotype and HLA-restricted cytolytic function and specificity. The ability of HVS to transform CTL may have an important role in the functional analysis of human antigen-specific CTL.

Original language	English (US)
Pages (from-to)	6317-6321
Number of pages	5
Journal	Journal of virology
Volume	67
Issue number	10
State	Published - Oct 1993

ASJC Scopus subject areas

Microbiology
Immunology
Insect Science
Virology

Cite this

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title = "Phenotypic and functional consequences of herpesvirus saimiri infection of human CD8+ cytotoxic T lymphocytes",

abstract = "Herpesvirus saimiri (HVS) was used to infect and transform human CD8+ cytotoxic T lymphocytes (CTL), and the phenotypic and functional consequences of HVS infection of CD8+ T lymphocytes were investigated. HVS-transformed CTL no longer require antigen restimulation yet maintain their phenotype and HLA-restricted cytolytic function and specificity. The ability of HVS to transform CTL may have an important role in the functional analysis of human antigen-specific CTL.",

author = "Berend, {Keith R.} and Jung, {Jae U.} and Boyle, {Terence J.} and DiMaio, {J. Michael} and Mungal, {Salvatore A.} and Desrosiers, {Ronald C.} and Lyerly, {H. Kim}",

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AU - Berend, Keith R.

AU - Jung, Jae U.

AU - Boyle, Terence J.

AU - DiMaio, J. Michael

AU - Mungal, Salvatore A.

AU - Desrosiers, Ronald C.

AU - Lyerly, H. Kim

PY - 1993/10

Y1 - 1993/10

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AB - Herpesvirus saimiri (HVS) was used to infect and transform human CD8+ cytotoxic T lymphocytes (CTL), and the phenotypic and functional consequences of HVS infection of CD8+ T lymphocytes were investigated. HVS-transformed CTL no longer require antigen restimulation yet maintain their phenotype and HLA-restricted cytolytic function and specificity. The ability of HVS to transform CTL may have an important role in the functional analysis of human antigen-specific CTL.

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Phenotypic and functional consequences of herpesvirus saimiri infection of human CD8⁺ cytotoxic T lymphocytes

Abstract

ASJC Scopus subject areas

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