Phenotypic and functional consequences of herpesvirus saimiri infection of human CD8+ cytotoxic T lymphocytes

Keith R. Berend, Jae U. Jung, Terence J. Boyle, J. Michael DiMaio, Salvatore A. Mungal, Ronald C. Desrosiers, H. Kim Lyerly

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35 Scopus citations

Abstract

Herpesvirus saimiri (HVS) was used to infect and transform human CD8+ cytotoxic T lymphocytes (CTL), and the phenotypic and functional consequences of HVS infection of CD8+ T lymphocytes were investigated. HVS-transformed CTL no longer require antigen restimulation yet maintain their phenotype and HLA-restricted cytolytic function and specificity. The ability of HVS to transform CTL may have an important role in the functional analysis of human antigen-specific CTL.

Original languageEnglish (US)
Pages (from-to)6317-6321
Number of pages5
JournalJournal of Virology
Volume67
Issue number10
Publication statusPublished - Oct 1993

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ASJC Scopus subject areas

  • Immunology

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Berend, K. R., Jung, J. U., Boyle, T. J., DiMaio, J. M., Mungal, S. A., Desrosiers, R. C., & Lyerly, H. K. (1993). Phenotypic and functional consequences of herpesvirus saimiri infection of human CD8+ cytotoxic T lymphocytes. Journal of Virology, 67(10), 6317-6321.