Abstract
The mechanisms of nonclassical export of signal peptide-less proteins remain insufficiently understood. Here, we demonstrate that stressinduced unconventional export of FGF1, a potent and ubiquitously expressed mitogenic and proangiogenic protein, is associated with and dependent on the formation of membrane blebs and localized cell surface exposure of phosphatidylserine (PS). In addition, we found that the differentiation of promonocytic cells results in massive FGF1 release, which also correlates with membrane blebbing and exposure of PS. These findings indicate that the externalization of acidic phospholipids could be used as a pharmacological target to regulate the availability of FGF1 in the organism.
Original language | English (US) |
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Pages (from-to) | 956-966 |
Number of pages | 11 |
Journal | Journal of Cellular Biochemistry |
Volume | 113 |
Issue number | 3 |
DOIs | |
State | Published - Mar 2012 |
Keywords
- Blebbing
- Fgf1
- Nonclassical Secretion
- Phosphatidylserine Exposure
- Plscr1
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Cell Biology