Phosphatonins: A new class of phosphate-regulating proteins

Susan C. Schiavi, Orson W. Moe

Research output: Contribution to journalArticle

53 Citations (Scopus)

Abstract

Purpose of review: There is an intimate relationship between phosphate and calcium homeostasis throughout the animal kingdom. One traditional assumption is that all phosphate-regulating hormones are primarily calcium-regulating hormones. Although the notion of a circulating substance dedicated to phosphate homeostasis has existed for more than a decade, it is not until recently that these hormones have been identified. The molecular characterization of these substances will prove to be critical for understanding phosphate physiology and clinical disorders of phosphate metabolism. Recent findings: This review will focus primarily on the first two proteins recently shown to have phosphatonin properties. Using three human diseases as models and a combination of positional cloning and differential gene expression, fibroblast growth factor 23 and frizzled-related protein 4 were shown to be associated with one or more of these diseases. Although both of these substances have phosphaturic action, their biological effects are likely to extend beyond epithelial phosphate transport. Summary: The phosphatonins are a growing family of substances that may act on multiple organs in autocrine, paracrine, and endocrine modes to regulate phosphate metabolism. As this list expands, the need for a more rigid definition of the term phosphatonin becomes evident. The identification and characterization of these phosphate-regulatory compounds will provide a clearer understanding of how individual phosphatonins regulate phosphate in normal and disease physiology.

Original languageEnglish (US)
Pages (from-to)423-430
Number of pages8
JournalCurrent Opinion in Nephrology and Hypertension
Volume11
Issue number4
DOIs
StatePublished - 2002

Fingerprint

Phosphates
Proteins
Hormones
Homeostasis
Organism Cloning
Calcium
Gene Expression

Keywords

  • Fibroblast growth factor 23
  • Frizzled-related protein 4
  • Phosphatonins
  • Phosphaturic

ASJC Scopus subject areas

  • Internal Medicine
  • Nephrology

Cite this

Phosphatonins : A new class of phosphate-regulating proteins. / Schiavi, Susan C.; Moe, Orson W.

In: Current Opinion in Nephrology and Hypertension, Vol. 11, No. 4, 2002, p. 423-430.

Research output: Contribution to journalArticle

@article{da0837d462334ab4aa8a3a6eb69dce88,
title = "Phosphatonins: A new class of phosphate-regulating proteins",
abstract = "Purpose of review: There is an intimate relationship between phosphate and calcium homeostasis throughout the animal kingdom. One traditional assumption is that all phosphate-regulating hormones are primarily calcium-regulating hormones. Although the notion of a circulating substance dedicated to phosphate homeostasis has existed for more than a decade, it is not until recently that these hormones have been identified. The molecular characterization of these substances will prove to be critical for understanding phosphate physiology and clinical disorders of phosphate metabolism. Recent findings: This review will focus primarily on the first two proteins recently shown to have phosphatonin properties. Using three human diseases as models and a combination of positional cloning and differential gene expression, fibroblast growth factor 23 and frizzled-related protein 4 were shown to be associated with one or more of these diseases. Although both of these substances have phosphaturic action, their biological effects are likely to extend beyond epithelial phosphate transport. Summary: The phosphatonins are a growing family of substances that may act on multiple organs in autocrine, paracrine, and endocrine modes to regulate phosphate metabolism. As this list expands, the need for a more rigid definition of the term phosphatonin becomes evident. The identification and characterization of these phosphate-regulatory compounds will provide a clearer understanding of how individual phosphatonins regulate phosphate in normal and disease physiology.",
keywords = "Fibroblast growth factor 23, Frizzled-related protein 4, Phosphatonins, Phosphaturic",
author = "Schiavi, {Susan C.} and Moe, {Orson W.}",
year = "2002",
doi = "10.1097/00041552-200207000-00009",
language = "English (US)",
volume = "11",
pages = "423--430",
journal = "Current Opinion in Nephrology and Hypertension",
issn = "1062-4821",
publisher = "Lippincott Williams and Wilkins",
number = "4",

}

TY - JOUR

T1 - Phosphatonins

T2 - A new class of phosphate-regulating proteins

AU - Schiavi, Susan C.

AU - Moe, Orson W.

PY - 2002

Y1 - 2002

N2 - Purpose of review: There is an intimate relationship between phosphate and calcium homeostasis throughout the animal kingdom. One traditional assumption is that all phosphate-regulating hormones are primarily calcium-regulating hormones. Although the notion of a circulating substance dedicated to phosphate homeostasis has existed for more than a decade, it is not until recently that these hormones have been identified. The molecular characterization of these substances will prove to be critical for understanding phosphate physiology and clinical disorders of phosphate metabolism. Recent findings: This review will focus primarily on the first two proteins recently shown to have phosphatonin properties. Using three human diseases as models and a combination of positional cloning and differential gene expression, fibroblast growth factor 23 and frizzled-related protein 4 were shown to be associated with one or more of these diseases. Although both of these substances have phosphaturic action, their biological effects are likely to extend beyond epithelial phosphate transport. Summary: The phosphatonins are a growing family of substances that may act on multiple organs in autocrine, paracrine, and endocrine modes to regulate phosphate metabolism. As this list expands, the need for a more rigid definition of the term phosphatonin becomes evident. The identification and characterization of these phosphate-regulatory compounds will provide a clearer understanding of how individual phosphatonins regulate phosphate in normal and disease physiology.

AB - Purpose of review: There is an intimate relationship between phosphate and calcium homeostasis throughout the animal kingdom. One traditional assumption is that all phosphate-regulating hormones are primarily calcium-regulating hormones. Although the notion of a circulating substance dedicated to phosphate homeostasis has existed for more than a decade, it is not until recently that these hormones have been identified. The molecular characterization of these substances will prove to be critical for understanding phosphate physiology and clinical disorders of phosphate metabolism. Recent findings: This review will focus primarily on the first two proteins recently shown to have phosphatonin properties. Using three human diseases as models and a combination of positional cloning and differential gene expression, fibroblast growth factor 23 and frizzled-related protein 4 were shown to be associated with one or more of these diseases. Although both of these substances have phosphaturic action, their biological effects are likely to extend beyond epithelial phosphate transport. Summary: The phosphatonins are a growing family of substances that may act on multiple organs in autocrine, paracrine, and endocrine modes to regulate phosphate metabolism. As this list expands, the need for a more rigid definition of the term phosphatonin becomes evident. The identification and characterization of these phosphate-regulatory compounds will provide a clearer understanding of how individual phosphatonins regulate phosphate in normal and disease physiology.

KW - Fibroblast growth factor 23

KW - Frizzled-related protein 4

KW - Phosphatonins

KW - Phosphaturic

UR - http://www.scopus.com/inward/record.url?scp=0036019490&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036019490&partnerID=8YFLogxK

U2 - 10.1097/00041552-200207000-00009

DO - 10.1097/00041552-200207000-00009

M3 - Article

C2 - 12105393

AN - SCOPUS:0036019490

VL - 11

SP - 423

EP - 430

JO - Current Opinion in Nephrology and Hypertension

JF - Current Opinion in Nephrology and Hypertension

SN - 1062-4821

IS - 4

ER -