Phosphorus-31 NMR of neuroblastoma clonal lines - Effect of cell confluency state and dibutyryl cyclic AMP

Jay W. Pettegrew, Thomas Glonek, Fred Baskin, Roger N. Rosenberg

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Phosphorus nuclear magnetic resonance is used to study changes in the levels of the major phosphate-containing intermediary metabolites concomitant with induced cellular differentiation in the N-18 and C-46 neuroblastoma clonal lines. The study reveals differences between the31P-NMR profiles of the two clonal lines and also striking differences attendant to dibutyryl cAMP-mediated morphological differentiation in the N-18 clone. Phosphorus-31 NMR would appear to provide a new technique with which to study genetic differentiation.

Original languageEnglish (US)
Pages (from-to)795-802
Number of pages8
JournalNeurochemical Research
Issue number6
Publication statusPublished - Dec 1979


ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry

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