Phosphorus-31 NMR of neuroblastoma clonal lines - Effect of cell confluency state and dibutyryl cyclic AMP

Jay W. Pettegrew, Thomas Glonek, Fred Baskin, Roger N. Rosenberg

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Phosphorus nuclear magnetic resonance is used to study changes in the levels of the major phosphate-containing intermediary metabolites concomitant with induced cellular differentiation in the N-18 and C-46 neuroblastoma clonal lines. The study reveals differences between the31P-NMR profiles of the two clonal lines and also striking differences attendant to dibutyryl cAMP-mediated morphological differentiation in the N-18 clone. Phosphorus-31 NMR would appear to provide a new technique with which to study genetic differentiation.

Original languageEnglish (US)
Pages (from-to)795-802
Number of pages8
JournalNeurochemical Research
Volume4
Issue number6
DOIs
StatePublished - Dec 1979

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Bucladesine
Neuroblastoma
Phosphorus
Nuclear magnetic resonance
Magnetic Resonance Spectroscopy
Clone Cells
Phosphates
Metabolites

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry

Cite this

Phosphorus-31 NMR of neuroblastoma clonal lines - Effect of cell confluency state and dibutyryl cyclic AMP. / Pettegrew, Jay W.; Glonek, Thomas; Baskin, Fred; Rosenberg, Roger N.

In: Neurochemical Research, Vol. 4, No. 6, 12.1979, p. 795-802.

Research output: Contribution to journalArticle

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