Phosphorus-31 NMR of neuroblastoma clonal lines - Effect of cell confluency state and dibutyryl cyclic AMP

Jay W. Pettegrew, Thomas Glonek, Fred Baskin, Roger N. Rosenberg

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

Phosphorus nuclear magnetic resonance is used to study changes in the levels of the major phosphate-containing intermediary metabolites concomitant with induced cellular differentiation in the N-18 and C-46 neuroblastoma clonal lines. The study reveals differences between the31P-NMR profiles of the two clonal lines and also striking differences attendant to dibutyryl cAMP-mediated morphological differentiation in the N-18 clone. Phosphorus-31 NMR would appear to provide a new technique with which to study genetic differentiation.

Original languageEnglish (US)
Pages (from-to)795-802
Number of pages8
JournalNeurochemical Research
Volume4
Issue number6
DOIs
StatePublished - Dec 1 1979

ASJC Scopus subject areas

  • Biochemistry
  • Cellular and Molecular Neuroscience

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