Phosphorylation of the cryptochrome 1 C-terminal tail regulates circadian period length

Peng Gao, Seung Hee Yoo, Kyung Jong Lee, Clark Rosensweig, Joseph S. Takahashi, Benjamin P. Chen, Carla B. Green

Research output: Contribution to journalArticle

39 Scopus citations

Abstract

Background: Cryptochromes (CRYs) are transcriptional repressors that are critical components of the circadian clock. Results: We have identified a phosphorylation site in the CRY1 tail that is negatively regulated by the DNA repair enzyme DNA-dependent protein kinase. Conclusion: Phosphorylation of CRY1 on Ser-588 increases its half-life and lengthens the circadian period. Significance: The C-terminal tail of CRY1 modulates period length.

Original languageEnglish (US)
Pages (from-to)35277-35286
Number of pages10
JournalJournal of Biological Chemistry
Volume288
Issue number49
DOIs
StatePublished - Dec 6 2013

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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