Phosphorylation of the liver X receptors

Mingyi Chen, Michelle N. Bradley, Simon W. Beaven, Peter Tontonoz

Research output: Contribution to journalArticle

43 Scopus citations

Abstract

The liver X receptors (LXRs) function as nutritional sensors for cholesterol and have important roles in lipid metabolism, glucose homeostasis, and inflammation. We provide the first evidence that LXRs are phosphorylated proteins. Mutational analysis and metabolic labeling indicate LXRα is phosphorylated on serine 198 in the hinge region. This is a consensus target for the MAPK family. A phosphorylation-deficient mutant, LXRα S198A, remains nuclear and responds to ligands like the wild-type protein. The biological significance of LXR phosphorylation remains to be elucidated but could provide a novel mechanism for the regulation of LXR signaling pathways and cellular metabolism.

Original languageEnglish (US)
Pages (from-to)4835-4841
Number of pages7
JournalFEBS Letters
Volume580
Issue number20
DOIs
StatePublished - Sep 4 2006

Keywords

  • Cholesterol metabolism
  • Liver X receptor
  • Phosphorylation

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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    Chen, M., Bradley, M. N., Beaven, S. W., & Tontonoz, P. (2006). Phosphorylation of the liver X receptors. FEBS Letters, 580(20), 4835-4841. https://doi.org/10.1016/j.febslet.2006.07.074