Physiologic and exogenous hormone effects on the endometrium: important aspects for the surgical pathologist

Mir Alikhan, Katja Gwin

Research output: Contribution to journalReview article

Abstract

The endometrium exhibits a unique physiology in its ability to cyclically respond to steroid hormones, resulting in morphologic changes that allow the pathologist's interpretation of proper endometrial function. Distinctive changes are also observed during times of physiologic hormonal changes, such as in pregnancy, or in pathologic and iatrogenic hormonal imbalances, as in certain functioning ovarian tumours and hormone therapy, respectively. The ubiquity of these states, in particular the widespread use of oral contraception, hormone replacement therapy, hormonal intrauterine devices, and nowadays frequent use of progestin as treatment for endometrial hyperplasia and carcinoma, requires that the pathologist be familiar with both the patient history as well as the histologic patterns specific to each entity in order to render an accurate, practical diagnosis for the clinician. Notably, some changes may mimic more worrisome lesions, and vigilance of these similarities and differential diagnosis is necessary in the evaluation of endometrial samples.

Original languageEnglish (US)
Pages (from-to)285-291
Number of pages7
JournalDiagnostic Histopathology
Volume23
Issue number7
DOIs
StatePublished - Jul 1 2017

Fingerprint

Endometrium
Hormones
Endometrial Hyperplasia
Intrauterine Devices
Hormone Replacement Therapy
Progestins
Endometrial Neoplasms
Contraception
Differential Diagnosis
Steroids
Pregnancy
Therapeutics
Neoplasms
Pathologists

Keywords

  • decidualization
  • endometrium
  • endometrium carcinoma
  • exogenous hormone
  • hyperplasia
  • IUD
  • progesterone

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology

Cite this

Physiologic and exogenous hormone effects on the endometrium : important aspects for the surgical pathologist. / Alikhan, Mir; Gwin, Katja.

In: Diagnostic Histopathology, Vol. 23, No. 7, 01.07.2017, p. 285-291.

Research output: Contribution to journalReview article

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