Physiological Actions of PTH and PTHrP IV: Vascular, Cardiovascular, and CNS Biology

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Abstract

This chapter gives an overview of PTH/PTHrP biology in the vasculature, emphasizing relationships with respect to cardiovascular biology and pathophysiology. Brief comment is given on central PTHrP and TIP39 actions that impact cardiovascular physiology-and exemplify the complexities of CNS regulation that have yet to be fully explored. Attention is then turned to chronic kidney disease-mineral and bone disorder (CKD-MBD) as a "perfect storm" of cardiometabolic risk arising in significant part from perturbed PTH1R signaling, and this discussion is used as a framework to highlight physiologically important interconnections within the emerging bone-vascular axis.

Original languageEnglish (US)
Title of host publicationThe Parathyroids
Subtitle of host publicationBasic and Clinical Concepts: Third Edition
PublisherElsevier Inc.
Pages187-201
Number of pages15
ISBN (Print)9780123971661
DOIs
StatePublished - Jan 1 2015

Keywords

  • Cardiomyocyte
  • Chronic kidney disease (CKD)
  • Coronary flow reserve (CFR)
  • Mineral and bone disorder (MBD)
  • PTH/PTHrP signaling
  • Pressor

ASJC Scopus subject areas

  • Medicine(all)

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