Physiological Actions of PTH and PTHrP IV

Vascular, Cardiovascular, and CNS Biology

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Abstract

This chapter gives an overview of PTH/PTHrP biology in the vasculature, emphasizing relationships with respect to cardiovascular biology and pathophysiology. Brief comment is given on central PTHrP and TIP39 actions that impact cardiovascular physiology-and exemplify the complexities of CNS regulation that have yet to be fully explored. Attention is then turned to chronic kidney disease-mineral and bone disorder (CKD-MBD) as a "perfect storm" of cardiometabolic risk arising in significant part from perturbed PTH1R signaling, and this discussion is used as a framework to highlight physiologically important interconnections within the emerging bone-vascular axis.

Original languageEnglish (US)
Title of host publicationThe Parathyroids
Subtitle of host publicationBasic and Clinical Concepts: Third Edition
PublisherElsevier Inc.
Pages187-201
Number of pages15
ISBN (Print)9780123971661
DOIs
StatePublished - Sep 5 2014

Fingerprint

Parathyroid Hormone-Related Protein
Blood Vessels
Cardiovascular Physiological Phenomena
Chronic Kidney Disease-Mineral and Bone Disorder
Bone and Bones

Keywords

  • Cardiomyocyte
  • Chronic kidney disease (CKD)
  • Coronary flow reserve (CFR)
  • Mineral and bone disorder (MBD)
  • Pressor
  • PTH/PTHrP signaling

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Towler, D. A. (2014). Physiological Actions of PTH and PTHrP IV: Vascular, Cardiovascular, and CNS Biology. In The Parathyroids: Basic and Clinical Concepts: Third Edition (pp. 187-201). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-397166-1.00012-6

Physiological Actions of PTH and PTHrP IV : Vascular, Cardiovascular, and CNS Biology. / Towler, Dwight A.

The Parathyroids: Basic and Clinical Concepts: Third Edition. Elsevier Inc., 2014. p. 187-201.

Research output: Chapter in Book/Report/Conference proceedingChapter

Towler, DA 2014, Physiological Actions of PTH and PTHrP IV: Vascular, Cardiovascular, and CNS Biology. in The Parathyroids: Basic and Clinical Concepts: Third Edition. Elsevier Inc., pp. 187-201. https://doi.org/10.1016/B978-0-12-397166-1.00012-6
Towler DA. Physiological Actions of PTH and PTHrP IV: Vascular, Cardiovascular, and CNS Biology. In The Parathyroids: Basic and Clinical Concepts: Third Edition. Elsevier Inc. 2014. p. 187-201 https://doi.org/10.1016/B978-0-12-397166-1.00012-6
Towler, Dwight A. / Physiological Actions of PTH and PTHrP IV : Vascular, Cardiovascular, and CNS Biology. The Parathyroids: Basic and Clinical Concepts: Third Edition. Elsevier Inc., 2014. pp. 187-201
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