Physiological, pathological, and engineered cell identity reprogramming in the central nervous system

Derek K. Smith, Lei Lei Wang, Chun Li Zhang

Research output: Contribution to journalReview article

4 Scopus citations

Abstract

Multipotent neural stem cells persist in restricted regions of the adult mammalian central nervous system. These proliferative cells differentiate into diverse neuron subtypes to maintain neural homeostasis. This endogenous process can be reprogrammed as a compensatory response to physiological cues, traumatic injury, and neurodegeneration. In addition to innate neurogenesis, recent research has demonstrated that new neurons can be engineered via cell identity reprogramming in non-neurogenic regions of the adult central nervous system. A comprehensive understanding of these reprogramming mechanisms will be essential to the development of therapeutic neural regeneration strategies that aim to improve functional recovery after injury and neurodegeneration. WIREs Dev Biol 2016, 5:499–517. doi: 10.1002/wdev.234. For further resources related to this article, please visit the WIREs website.

Original languageEnglish (US)
Pages (from-to)499-517
Number of pages19
JournalWiley Interdisciplinary Reviews: Developmental Biology
Volume5
Issue number4
DOIs
StatePublished - Jul 1 2016

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology
  • Molecular Biology

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