TY - JOUR
T1 - Physiology and Pathophysiology of Mechanically Activated PIEZO Channels
AU - Syeda, Ruhma
N1 - Publisher Copyright:
© 2021 Annual Reviews Inc.. All rights reserved.
PY - 2021/7/8
Y1 - 2021/7/8
N2 - Nearly all structures in our body experience mechanical forces. At a molecular scale, these forces are detected by ion channels that function as mechanotransducers converting physical forces into electrochemical responses. Here we focus on PIEZOs, a family of mechanically activated ion channels comprising PIEZO1 and PIEZO2. The significance of these channels is highlighted by their roles in touch and pain sensation as well as in cardiovascular and respiratory physiology, among others. Moreover, mutations in PIEZOs cause somatosensory, proprioceptive, and blood disorders. The goal here is to present the diverse physiology and pathophysiology of these unique channels, discuss ongoing research and critical gaps in the field, and explore the pharmaceutical interest in targeting PIEZOs for therapeutic development.
AB - Nearly all structures in our body experience mechanical forces. At a molecular scale, these forces are detected by ion channels that function as mechanotransducers converting physical forces into electrochemical responses. Here we focus on PIEZOs, a family of mechanically activated ion channels comprising PIEZO1 and PIEZO2. The significance of these channels is highlighted by their roles in touch and pain sensation as well as in cardiovascular and respiratory physiology, among others. Moreover, mutations in PIEZOs cause somatosensory, proprioceptive, and blood disorders. The goal here is to present the diverse physiology and pathophysiology of these unique channels, discuss ongoing research and critical gaps in the field, and explore the pharmaceutical interest in targeting PIEZOs for therapeutic development.
KW - channelopathies
KW - mechanically activated PIEZO channels
KW - mechanopathologies
KW - mechanotransduction
KW - proprioception
KW - somatosensation
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U2 - 10.1146/annurev-neuro-093020-120939
DO - 10.1146/annurev-neuro-093020-120939
M3 - Article
C2 - 34236889
AN - SCOPUS:85109545815
SN - 0147-006X
VL - 44
SP - 383
EP - 402
JO - Annual Review of Neuroscience
JF - Annual Review of Neuroscience
ER -