Pictures in cell biology structures of nuclear-transport components

Yuh Min Chook, Gino Cingolani, Elena Conti, Murray Stewart, Ingrid Vetter, Alfred Wittinghofer

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

The past three years have seen the solution of several nuclear transport component structures and recently of the structure of a regulator bound to part of a nuclear pore complex (NPC) protein. These structures have provided a wealth of valuable information about the proteins involved and suggested strategies for further investigation of their properties. We do not have space here to go into detail about this information, so instead we are illustrating the structures and providing primary references enabling interested readers to find further information. On this page, we are concentrating on the GTPase Ran and proteins that modulate its activity, and on the facing page are other transport factors, some of which also interact directly with Ran. Notably absent at the moment are the nuclear pore complex components, apart from one domain of RanBP2. Only when these are characterized fully will we really be able to understand how transport substrates move across the nuclear envelope.

Original languageEnglish (US)
Pages (from-to)310-311
Number of pages2
JournalTrends in Cell Biology
Volume9
Issue number8
DOIs
StatePublished - Aug 1 1999

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ran GTP-Binding Protein
Nuclear Pore Complex Proteins
Nuclear Pore
Cell Nucleus Active Transport
GTP Phosphohydrolases
Nuclear Envelope
Cell Biology
Proteins

ASJC Scopus subject areas

  • Cell Biology

Cite this

Chook, Y. M., Cingolani, G., Conti, E., Stewart, M., Vetter, I., & Wittinghofer, A. (1999). Pictures in cell biology structures of nuclear-transport components. Trends in Cell Biology, 9(8), 310-311. https://doi.org/10.1016/S0962-8924(99)01610-4

Pictures in cell biology structures of nuclear-transport components. / Chook, Yuh Min; Cingolani, Gino; Conti, Elena; Stewart, Murray; Vetter, Ingrid; Wittinghofer, Alfred.

In: Trends in Cell Biology, Vol. 9, No. 8, 01.08.1999, p. 310-311.

Research output: Contribution to journalArticle

Chook, YM, Cingolani, G, Conti, E, Stewart, M, Vetter, I & Wittinghofer, A 1999, 'Pictures in cell biology structures of nuclear-transport components', Trends in Cell Biology, vol. 9, no. 8, pp. 310-311. https://doi.org/10.1016/S0962-8924(99)01610-4
Chook, Yuh Min ; Cingolani, Gino ; Conti, Elena ; Stewart, Murray ; Vetter, Ingrid ; Wittinghofer, Alfred. / Pictures in cell biology structures of nuclear-transport components. In: Trends in Cell Biology. 1999 ; Vol. 9, No. 8. pp. 310-311.
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