Piezo-electric coupling of membrane proteins

Tian Y. Tsong, Vladislav S. Markin

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

A membrane protein responds to pressure perturbation if the molar volume of its various conformational states has different values, or if these states have different contact areas with the lipid bilayer. An oscillating pressure can then drive the protein to oscillate among its various conformational states within the catalytic cycle. It is shown that this property of an ion transporter enables it to absorb energy from the pressure wave to actively pump an ion against its concentration gradient, thus converting the pressure energy into the electrochemical potential energy of an ion, and vice versa. An electroformational coupling model developed earlier is applied to formulate an efficient piezoelectric transducer. With reasonable assumptions on the cell membrane parameters, the model can easily generate a membrane potential on the order of 100 mV.

Original languageEnglish (US)
Title of host publicationBiomedical Engineering Perspectives
Subtitle of host publicationHealth Care Technologies for the 1990's and Beyond
PublisherPubl by IEEE
Number of pages1
Editionpt 4
ISBN (Print)0879425598
StatePublished - Dec 1 1990
EventProceedings of the 12th Annual International Conference of the IEEE Engineering in Medicine and Biology Society - Philadelphia, PA, USA
Duration: Nov 1 1990Nov 4 1990

Publication series

NameProceedings of the Annual Conference on Engineering in Medicine and Biology
Numberpt 4
ISSN (Print)0589-1019

Other

OtherProceedings of the 12th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
CityPhiladelphia, PA, USA
Period11/1/9011/4/90

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ASJC Scopus subject areas

  • Signal Processing
  • Biomedical Engineering
  • Computer Vision and Pattern Recognition
  • Health Informatics

Cite this

Tsong, T. Y., & Markin, V. S. (1990). Piezo-electric coupling of membrane proteins. In Biomedical Engineering Perspectives: Health Care Technologies for the 1990's and Beyond (pt 4 ed.). (Proceedings of the Annual Conference on Engineering in Medicine and Biology; No. pt 4). Publ by IEEE.