Piezo1 Channels Are Inherently Mechanosensitive

Ruhma Syeda, Maria N. Florendo, Charles D. Cox, Jennifer M. Kefauver, Jose S. Santos, Boris Martinac, Ardem Patapoutian

Research output: Contribution to journalArticle

86 Citations (Scopus)

Abstract

The conversion of mechanical force to chemical signals is critical for many biological processes, including the senses of touch, pain, and hearing. Mechanosensitive ion channels play a key role in sensing the mechanical stimuli experienced by various cell types and are present in organisms from bacteria to mammals. Bacterial mechanosensitive channels are characterized thoroughly, but less is known about their counterparts in vertebrates. Piezos have been recently established as ion channels required for mechanotransduction in disparate cell types in vitro and in vivo. Overexpression of Piezos in heterologous cells gives rise to large mechanically activated currents; however, it is unclear whether Piezos are inherently mechanosensitive or rely on alternate cellular components to sense mechanical stimuli. Here, we show that mechanical perturbations of the lipid bilayer alone are sufficient to activate Piezo channels, illustrating their innate ability as molecular force transducers.

Original languageEnglish (US)
Pages (from-to)1739-1746
Number of pages8
JournalCell Reports
Volume17
Issue number7
DOIs
StatePublished - Nov 8 2016

Fingerprint

Ion Channels
Lipid bilayers
Mammals
Audition
Biological Phenomena
Transducers
Bacteria
Aptitude
Touch
Lipid Bilayers
Hearing
Vertebrates
Pain

Keywords

  • lipid bilayer
  • mechanosensitive ion channel
  • mechanotransduction
  • membrane asymmetry
  • membrane tension
  • Piezo1

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Syeda, R., Florendo, M. N., Cox, C. D., Kefauver, J. M., Santos, J. S., Martinac, B., & Patapoutian, A. (2016). Piezo1 Channels Are Inherently Mechanosensitive. Cell Reports, 17(7), 1739-1746. https://doi.org/10.1016/j.celrep.2016.10.033

Piezo1 Channels Are Inherently Mechanosensitive. / Syeda, Ruhma; Florendo, Maria N.; Cox, Charles D.; Kefauver, Jennifer M.; Santos, Jose S.; Martinac, Boris; Patapoutian, Ardem.

In: Cell Reports, Vol. 17, No. 7, 08.11.2016, p. 1739-1746.

Research output: Contribution to journalArticle

Syeda, R, Florendo, MN, Cox, CD, Kefauver, JM, Santos, JS, Martinac, B & Patapoutian, A 2016, 'Piezo1 Channels Are Inherently Mechanosensitive', Cell Reports, vol. 17, no. 7, pp. 1739-1746. https://doi.org/10.1016/j.celrep.2016.10.033
Syeda R, Florendo MN, Cox CD, Kefauver JM, Santos JS, Martinac B et al. Piezo1 Channels Are Inherently Mechanosensitive. Cell Reports. 2016 Nov 8;17(7):1739-1746. https://doi.org/10.1016/j.celrep.2016.10.033
Syeda, Ruhma ; Florendo, Maria N. ; Cox, Charles D. ; Kefauver, Jennifer M. ; Santos, Jose S. ; Martinac, Boris ; Patapoutian, Ardem. / Piezo1 Channels Are Inherently Mechanosensitive. In: Cell Reports. 2016 ; Vol. 17, No. 7. pp. 1739-1746.
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