Pilot clinical study investigating the thermal physiology of breast cancer via high-resolution infrared imaging

Adolfo Lozano, Jody C. Hayes, Lindsay M. Compton, Fatemeh Hassanipour

Research output: Contribution to journalArticlepeer-review

Abstract

This descriptive study investigates breast thermal characteristics in females histologically diagnosed with unilateral breast cancer and in their contralateral normal breasts. The multi-institutional clinical pilot study was reviewed and approved by the Institutional Review Boards (IRBs) at participating institutions. Eleven female subjects with radiologic breast abnormalities were enrolled in the study between June 2019 and September 2019 after informed consent was obtained. Static infrared images were recorded for each subject. The Wilcoxon signed rank test was used to conduct paired comparisons in temperature data between breasts among the eight histologically diagnosed breast cancer subjects (n = 8). Localized temperatures of cancerous breast lesions were significantly warmer than corresponding regions in contralateral breasts (34.0 ± 0.9 °C vs. 33.2 ± 0.5 °C, p = 0.0142, 95% CI 0.25–1.5 °C). Generalized temperatures over cancerous breasts, in contrast, were not significantly warmer than corresponding regions in contralateral breasts (33.9 ± 0.8 °C vs. 33.4 ± 0.4 °C, p = 0.0625, 95% CI −0.05–1.45 °C). Among the breast cancers enrolled, breast cancers elevated temperatures locally at the site of the lesion (localized hyperthermia), but not over the entire breast (generalized hyperthermia).

Original languageEnglish (US)
Article number86
JournalBioengineering
Volume8
Issue number7
DOIs
StatePublished - Jul 2021

Keywords

  • Breast cancer
  • Hyperthermia
  • Infrared imaging
  • Thermal imaging

ASJC Scopus subject areas

  • Bioengineering

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