Pilot, prospective, randomized, double-masked, placebo-controlled clinical trial of an omega-3 supplement for dry eye

Jadwiga Cristina Wojtowicz, Igor Butovich, Eduardo Uchiyama, Joel Aronowicz, Shawn Agee, James P McCulley

Research output: Contribution to journalArticle

88 Citations (Scopus)

Abstract

Purpose: To investigate the potential effect of dietary supplementation with omega-3 fatty acid on lipid composition of meibum, aqueous tear evaporation, and tear volume in patients with dry eye. Methods: In a pilot, prospective, randomized, double-masked study, patients with dry eye received a daily dose of fish oil, containing 450 mg of eicosapentaenoic acid, 300 mg of docosahexaenoic acid, and 1000 mg of flaxseed oil (TheraTears Nutrition; Advanced Vision Research, Woburn, MA) for 90 days. There were 2 patient visits: baseline and final. At these visits, patients completed the ocular surface disease index to score subjective symptoms, and slit-lamp examinations, breakup time, corneal staining, Schirmer type I, fluorophotometry, evaporometry, and collection of meibomian gland secretion samples for lipid composition analysis were performed. Results: A total of 36 patients with dry eye completed the study. At the end of the study, 70% of the patients became asymptomatic, whereas for the placebo group, 7% of the symptomatic patients became asymptomatic. Schirmer testing and fluorophotometry suggested that the omega-3 supplement increased tear secretion. The lipid composition of the samples collected from the omega-3 group was found to be very similar to that from the placebo group. No trends between groups were seen for other objective parameters. Conclusions: Dietary supplementation with omega-3 fatty acids in dry eye showed no significant effect in meibum lipid composition or aqueous tear evaporation rate. On the other hand, the average tear production and tear volume was increased in the omega-3 group as indicated by both Schirmer testing and fluorophotometry.

Original languageEnglish (US)
Pages (from-to)308-314
Number of pages7
JournalCornea
Volume30
Issue number3
DOIs
StatePublished - Mar 2011

Fingerprint

Controlled Clinical Trials
Tears
Placebos
Fluorophotometry
Lipids
Omega-3 Fatty Acids
Dietary Supplements
Meibomian Glands
Linseed Oil
Eicosapentaenoic Acid
Eye Diseases
Docosahexaenoic Acids
Fish Oils
Double-Blind Method
Staining and Labeling
Research

Keywords

  • dry eye
  • lipid composition
  • meibum
  • omega-3 fatty acid
  • tear evaporation

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Pilot, prospective, randomized, double-masked, placebo-controlled clinical trial of an omega-3 supplement for dry eye. / Wojtowicz, Jadwiga Cristina; Butovich, Igor; Uchiyama, Eduardo; Aronowicz, Joel; Agee, Shawn; McCulley, James P.

In: Cornea, Vol. 30, No. 3, 03.2011, p. 308-314.

Research output: Contribution to journalArticle

Wojtowicz, Jadwiga Cristina ; Butovich, Igor ; Uchiyama, Eduardo ; Aronowicz, Joel ; Agee, Shawn ; McCulley, James P. / Pilot, prospective, randomized, double-masked, placebo-controlled clinical trial of an omega-3 supplement for dry eye. In: Cornea. 2011 ; Vol. 30, No. 3. pp. 308-314.
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