Pilot results of in vivo brain glutathione measurements in stroke patients

Li An, Krishna A. Dani, Jun Shen, Steven Warach

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Measurement of glutathione concentration for the study of redox status in subjects with neurological disease has been limited to peripheral markers. We recruited 19 subjects with large strokes. Using magnetic resonance spectroscopy we measured brain glutathione concentration in the stroke region and in healthy tissue to calculate a glutathione-ratio. Elevated glutathione-ratio was observed in subacute (72 hours) subjects without hemorrhagic transformation (mean1.19, P0.03, n6). No trend was seen when all subjects were considered (n19, 3 to 754 hours, range0.45 to 1.41). This technique can detect glutathione changes because of disease, and may be valuable in clinical trials of stroke and other neurological diseases.

Original languageEnglish (US)
Pages (from-to)2118-2121
Number of pages4
JournalJournal of Cerebral Blood Flow and Metabolism
Volume32
Issue number12
DOIs
StatePublished - Dec 1 2012

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Keywords

  • glutathione
  • magnetic resonance imaging
  • magnetic resonance spectroscopy
  • oxidative stress
  • stroke

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine

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