Pin1 and PKMζ sequentially control dendritic protein synthesis

Pamela R. Westmark, Cara J. Westmark, SuQing Wang, Jonathan Levenson, Kenneth J. O'Riordan, Corinna Burger, James S. Malter

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

Some forms of learning and memory and their electrophysiologic correlate, long-term potentiation (LTP), require dendritic translation. We demonstrate that Pin1 (protein interacting with NIMA 1), a peptidyl-prolyl isomerase, is present in dendritic spines and shafts and inhibits protein synthesis induced by gluta-matergic signaling. Pin1 suppression increased dendritic translation, possibly through eukaryotic translation initiation factor 4E (eIF4E) and eIF4E binding proteins 1 and 2 (4E-BP1/2). Consistent with increased protein synthesis, hippocampal slices from Pin-/- mice had normal early LTP (E-LTP) but significantly enhanced late LTP (L-LTP) compared to wild-type controls. Protein kinase C ζ (PKCζ) and protein kinase M ζ (PKMζ) were increased in Pin1-/- mouse brain, and their activity was required to maintain dendritic translation. PKMζ interacted with and inhibited Pin1 by phosphorylating serine 16. Therefore, glutamate-induced, dendritic protein synthesis is sequentially regulated by Pin1 and PKMζ signaling.

Original languageEnglish (US)
JournalScience Signaling
Volume3
Issue number112
DOIs
StatePublished - Mar 9 2010

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Protein Kinase C
Long-Term Potentiation
Proteins
Eukaryotic Initiation Factor-4E
Eukaryotic Initiation Factors
Peptidylprolyl Isomerase
Dendritic Spines
NIMA-Related Kinases
Serine
Glutamic Acid
Brain
Carrier Proteins
Learning
Data storage equipment

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology

Cite this

Westmark, P. R., Westmark, C. J., Wang, S., Levenson, J., O'Riordan, K. J., Burger, C., & Malter, J. S. (2010). Pin1 and PKMζ sequentially control dendritic protein synthesis. Science Signaling, 3(112). https://doi.org/10.1126/scisignal.2000451

Pin1 and PKMζ sequentially control dendritic protein synthesis. / Westmark, Pamela R.; Westmark, Cara J.; Wang, SuQing; Levenson, Jonathan; O'Riordan, Kenneth J.; Burger, Corinna; Malter, James S.

In: Science Signaling, Vol. 3, No. 112, 09.03.2010.

Research output: Contribution to journalArticle

Westmark, PR, Westmark, CJ, Wang, S, Levenson, J, O'Riordan, KJ, Burger, C & Malter, JS 2010, 'Pin1 and PKMζ sequentially control dendritic protein synthesis', Science Signaling, vol. 3, no. 112. https://doi.org/10.1126/scisignal.2000451
Westmark PR, Westmark CJ, Wang S, Levenson J, O'Riordan KJ, Burger C et al. Pin1 and PKMζ sequentially control dendritic protein synthesis. Science Signaling. 2010 Mar 9;3(112). https://doi.org/10.1126/scisignal.2000451
Westmark, Pamela R. ; Westmark, Cara J. ; Wang, SuQing ; Levenson, Jonathan ; O'Riordan, Kenneth J. ; Burger, Corinna ; Malter, James S. / Pin1 and PKMζ sequentially control dendritic protein synthesis. In: Science Signaling. 2010 ; Vol. 3, No. 112.
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