Pinning down signaling in the immune system: The role of the peptidyl-prolyl isomerase pin1 in immune cell function

Stephane Esnault, Zong Jian Shen, James S. Malter

Research output: Contribution to journalReview articlepeer-review

36 Scopus citations

Abstract

The peptidyl prolyl isomerase (PPIase) Pin1 has been recently implicated in cell cycle control and neuropathologies. There is now growing evidence that Pin1 plays an important role in the immune system and does so differentially from the related PPIases, cyclophilinA and FKBP. This review describes how Pin1 modulates cytokine expression by activated T cells and eosinophils and participates in T-cell and eosinophil apoptotic decisions both in vitro and in vivo. We highlight several possible immunologic diseases, including asthma, as well as organ transplant rejection, where anti-Pin1 therapeutics maybe of value.

Original languageEnglish (US)
Pages (from-to)45-60
Number of pages16
JournalCritical Reviews in Immunology
Volume28
Issue number1
StatePublished - 2008

Keywords

  • Asthma
  • Eosinophil
  • Lymphocyte
  • Pin1
  • Transplantation
  • mRNA decay

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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