Pituitary abnormalities in eating disorders: Further evidence from MRI studies

P. Murali Doraiswamy, K. Ranga Krishnan, Orest B. Boyko, Mustafa H. Husain, Gary S. Figiel, Vincent J. Palese, P. Rodrigo Escalona, Sunjay A. Shah, William M. Mcdonald, W. J Kenneth Rockwell, Everett H. Ellinwood

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

Doraiswamy, P. Murali, K. Ranga Krishnan, Orest B. Boyko, Mustafa M. Husain, Gary S. Figiel, Vincent J. Palese P. Rodrigo Escalona, Sunjay A. Shah, William M. McDonald W.J. Kenneth Rockwell, and Everett H. Ellinwood Jr.: Pituitary Abnormalities in Eating Disorders: Further Evidence from MRI Studies. Prog. Neuro-Psychopharmacol. & Biol. Psychiat. 1991, 15:351-356. 1. 1. The frequent occurrence of hypothalamo-pituitary dysfunction in patients with eating disorders as well as prior reports that nutritional and endocrine status influence pituitary morphology, led us to hypothesize that pituitary size and shape may be altered in patients with eating disorders. 2. 2. Magnetic resonance imaging (MRI) does not use ionizing radiation and is currently one of the most feasible modalities available to study the pituitary gland in vivo. Using MRI, we have previously reported in a preliminary study that female patients with eating disorders had significantly smaller pituitary glands than controls. In addition MRI excluded any pituitary mass lesions. 3. 3. In this report, we confirm our previous MRI findings and provide further evidence of pituitary abnormalities In an expanded sample of eating disorder patients. Preliminary data on pituitary volume estimates from MRI scans are provided for a subset of patients arid controls.

Original languageEnglish (US)
Pages (from-to)351-356
Number of pages6
JournalProgress in Neuropsychopharmacology and Biological Psychiatry
Volume15
Issue number3
DOIs
StatePublished - 1991

Keywords

  • MRI
  • anorexia
  • bulimia
  • hypothalamus
  • pituitary gland

ASJC Scopus subject areas

  • Pharmacology
  • Biological Psychiatry

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    Doraiswamy, P. M., Krishnan, K. R., Boyko, O. B., Husain, M. H., Figiel, G. S., Palese, V. J., Escalona, P. R., Shah, S. A., Mcdonald, W. M., Rockwell, W. J. K., & Ellinwood, E. H. (1991). Pituitary abnormalities in eating disorders: Further evidence from MRI studies. Progress in Neuropsychopharmacology and Biological Psychiatry, 15(3), 351-356. https://doi.org/10.1016/0278-5846(91)90066-A