Placental expression of the nuclear receptors for oxysterols LXRα and LXRβ during mouse and human development

Geoffroy Marceau, David H. Volle, Denis Gallot, David J. Mangelsdorf, Vincent Sapin, Jean Marc A Lobaccaro

Research output: Contribution to journalArticle

22 Scopus citations

Abstract

Ontogenesis and localization expression of genes encoding for the nuclear receptors for oxysterols (lxrα and lxrβ) were investigated in human and mouse placenta during gestation. Both mRNAs were detectable in the placentation throughout the gestation (from 7 days postcoitum and 6th week of gestation in mouse and human, respectively) by Northern blots or RT-PCR experiments. Lxrα showed a higher accumulation in the mouse yolk sac. In situ hybridization pointed a specific expression of lxrα in the human amniotic membranes.

Original languageEnglish (US)
Pages (from-to)175-181
Number of pages7
JournalAnatomical Record - Part A Discoveries in Molecular, Cellular, and Evolutionary Biology
Volume283
Issue number1
DOIs
StatePublished - Mar 1 2005

Keywords

  • Amniotic membranes
  • Liver receptors
  • Nuclear receptors
  • Placenta
  • Yolk sac

ASJC Scopus subject areas

  • Anatomy
  • Agricultural and Biological Sciences (miscellaneous)

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