Placental expression of the nuclear receptors for oxysterols LXRα and LXRβ during mouse and human development

Geoffroy Marceau, David H. Volle, Denis Gallot, David J. Mangelsdorf, Vincent Sapin, Jean Marc A Lobaccaro

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Ontogenesis and localization expression of genes encoding for the nuclear receptors for oxysterols (lxrα and lxrβ) were investigated in human and mouse placenta during gestation. Both mRNAs were detectable in the placentation throughout the gestation (from 7 days postcoitum and 6th week of gestation in mouse and human, respectively) by Northern blots or RT-PCR experiments. Lxrα showed a higher accumulation in the mouse yolk sac. In situ hybridization pointed a specific expression of lxrα in the human amniotic membranes.

Original languageEnglish (US)
Pages (from-to)175-181
Number of pages7
JournalAnatomical Record - Part A Discoveries in Molecular, Cellular, and Evolutionary Biology
Volume283
Issue number1
DOIs
StatePublished - Mar 2005

Fingerprint

human development
Human Development
pregnancy
Pregnancy
receptors
mice
Placentation
Yolk Sac
Amnion
yolk sac
placenta
Northern blotting
Northern Blotting
in situ hybridization
Placenta
In Situ Hybridization
ontogeny
reverse transcriptase polymerase chain reaction
membrane
Gene Expression

Keywords

  • Amniotic membranes
  • Liver receptors
  • Nuclear receptors
  • Placenta
  • Yolk sac

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Anatomy

Cite this

Placental expression of the nuclear receptors for oxysterols LXRα and LXRβ during mouse and human development. / Marceau, Geoffroy; Volle, David H.; Gallot, Denis; Mangelsdorf, David J.; Sapin, Vincent; Lobaccaro, Jean Marc A.

In: Anatomical Record - Part A Discoveries in Molecular, Cellular, and Evolutionary Biology, Vol. 283, No. 1, 03.2005, p. 175-181.

Research output: Contribution to journalArticle

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