Placental transfer of cefoperazone and sulbactam in the isolated in vitro perfused human placenta

Stephen J. Fortunato, Roger E. Bawdon, Michel G Baum

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

The transfer of cefoperazone and sulbactam across the human placenta was studied qualitatively and quantitatively with the isolated in vitro bidirectiohally perfused human placental lobule. Clearance indexes for both cefoperazone and sulbactam were derived. The absence of active transport and facilitated diffusion were documented, implying simple diffusion as the mechanism of placental transfer for both drugs. Placental tissue levels were also studied.

Original languageEnglish (US)
Pages (from-to)1002-1006
Number of pages5
JournalAmerican Journal of Obstetrics and Gynecology
Volume159
Issue number4
DOIs
StatePublished - Jan 1 1988

Fingerprint

Cefoperazone
Sulbactam
Placenta
Facilitated Diffusion
Active Biological Transport
Pharmaceutical Preparations
In Vitro Techniques

Keywords

  • cefoperazone
  • human
  • in vitro placental perfusion
  • Placenta
  • placental transfer
  • sulbactam

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Placental transfer of cefoperazone and sulbactam in the isolated in vitro perfused human placenta. / Fortunato, Stephen J.; Bawdon, Roger E.; Baum, Michel G.

In: American Journal of Obstetrics and Gynecology, Vol. 159, No. 4, 01.01.1988, p. 1002-1006.

Research output: Contribution to journalArticle

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