Placental transfer of cefoperazone and sulbactam in the isolated in vitro perfused human placenta

Stephen J. Fortunato, Roger E. Bawdon, Michel G Baum

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

The transfer of cefoperazone and sulbactam across the human placenta was studied qualitatively and quantitatively with the isolated in vitro bidirectiohally perfused human placental lobule. Clearance indexes for both cefoperazone and sulbactam were derived. The absence of active transport and facilitated diffusion were documented, implying simple diffusion as the mechanism of placental transfer for both drugs. Placental tissue levels were also studied.

Original languageEnglish (US)
Pages (from-to)1002-1006
Number of pages5
JournalAmerican Journal of Obstetrics and Gynecology
Volume159
Issue number4
DOIs
Publication statusPublished - Jan 1 1988

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Keywords

  • cefoperazone
  • human
  • in vitro placental perfusion
  • Placenta
  • placental transfer
  • sulbactam

ASJC Scopus subject areas

  • Obstetrics and Gynecology

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