Planar cell polarity and vertebrate organogenesis

Courtney Karner, Keith A. Wharton, Thomas J. Carroll

Research output: Contribution to journalReview article

75 Scopus citations

Abstract

In addition to being polarized along their apical/basal axis, cells composing most (if not all) organs are also polarized in a plane vertical to the A/B axis. Recent studies indicate that this so-called planar cell polarity (PCP) plays an essential role in the formation of multiple organ systems regulating directed cell migrations, polarized cell division and proper differentiation. In this review we will discuss the molecular mechanisms regulating PCP, including the hypothesized roles for Wnt ligands in this process, and its roles in vertebrate organogenesis.

Original languageEnglish (US)
Pages (from-to)194-203
Number of pages10
JournalSeminars in Cell and Developmental Biology
Volume17
Issue number2
DOIs
StatePublished - Apr 2006

Keywords

  • Convergent extension
  • Organogenesis
  • Planar cell polarity
  • Tissue polarity
  • Wnt

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

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