Planar cell polarity and vertebrate organogenesis

Courtney Karner; Keith A. Wharton; Thomas J. Carroll

doi:10.1016/j.semcdb.2006.05.003

Planar cell polarity and vertebrate organogenesis

Courtney Karner, Keith A. Wharton, Thomas J. Carroll

Research output: Contribution to journal › Review article › peer-review

84 Scopus citations

Abstract

In addition to being polarized along their apical/basal axis, cells composing most (if not all) organs are also polarized in a plane vertical to the A/B axis. Recent studies indicate that this so-called planar cell polarity (PCP) plays an essential role in the formation of multiple organ systems regulating directed cell migrations, polarized cell division and proper differentiation. In this review we will discuss the molecular mechanisms regulating PCP, including the hypothesized roles for Wnt ligands in this process, and its roles in vertebrate organogenesis.

Original language	English (US)
Pages (from-to)	194-203
Number of pages	10
Journal	Seminars in Cell and Developmental Biology
Volume	17
Issue number	2
DOIs	https://doi.org/10.1016/j.semcdb.2006.05.003
State	Published - Apr 2006

Keywords

Convergent extension
Organogenesis
Planar cell polarity
Tissue polarity
Wnt

ASJC Scopus subject areas

Developmental Biology
Cell Biology

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10.1016/j.semcdb.2006.05.003

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title = "Planar cell polarity and vertebrate organogenesis",

abstract = "In addition to being polarized along their apical/basal axis, cells composing most (if not all) organs are also polarized in a plane vertical to the A/B axis. Recent studies indicate that this so-called planar cell polarity (PCP) plays an essential role in the formation of multiple organ systems regulating directed cell migrations, polarized cell division and proper differentiation. In this review we will discuss the molecular mechanisms regulating PCP, including the hypothesized roles for Wnt ligands in this process, and its roles in vertebrate organogenesis.",

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AU - Wharton, Keith A.

AU - Carroll, Thomas J.

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N2 - In addition to being polarized along their apical/basal axis, cells composing most (if not all) organs are also polarized in a plane vertical to the A/B axis. Recent studies indicate that this so-called planar cell polarity (PCP) plays an essential role in the formation of multiple organ systems regulating directed cell migrations, polarized cell division and proper differentiation. In this review we will discuss the molecular mechanisms regulating PCP, including the hypothesized roles for Wnt ligands in this process, and its roles in vertebrate organogenesis.

AB - In addition to being polarized along their apical/basal axis, cells composing most (if not all) organs are also polarized in a plane vertical to the A/B axis. Recent studies indicate that this so-called planar cell polarity (PCP) plays an essential role in the formation of multiple organ systems regulating directed cell migrations, polarized cell division and proper differentiation. In this review we will discuss the molecular mechanisms regulating PCP, including the hypothesized roles for Wnt ligands in this process, and its roles in vertebrate organogenesis.

KW - Convergent extension

KW - Organogenesis

KW - Planar cell polarity

KW - Tissue polarity

KW - Wnt

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JO - Seminars in Cell and Developmental Biology

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ER -

Planar cell polarity and vertebrate organogenesis

Abstract

Keywords

ASJC Scopus subject areas

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