Planar cell polarity in kidney development and disease.

Thomas J. Carroll, Amrita Das

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Planar cell polarity (PCP) describes the coordinated polarization of tissue cells in a direction that is orthogonal to their apical/basal axis. In the last several years, studies in flies and vertebrates have defined evolutionarily conserved pathways that establish and maintain PCP in various cellular contexts. Defective responses to the polarizing signal(s) have deleterious effects on the development and repair of a wide variety of organs/tissues. In this review, we cover the known and hypothesized roles for PCP in the metanephric kidney. We highlight the similarities and differences in PCP establishment in this organ compared with flies, especially the role of Wnt signaling in this process. Finally, we present a model whereby the signal(s) that organizes PCP in the kidney epithelium, at least in part, comes from the adjacent stromal fibroblasts.

Original languageEnglish (US)
Pages (from-to)180-190
Number of pages11
JournalOrganogenesis
Volume7
Issue number3
StatePublished - Jul 2011

Fingerprint

Cell Polarity
Kidney Diseases
Tissue
Fibroblasts
Repair
Diptera
Polarization
Kidney
Vertebrates
Epithelium

ASJC Scopus subject areas

  • Developmental Biology
  • Embryology
  • Transplantation
  • Biomedical Engineering

Cite this

Planar cell polarity in kidney development and disease. / Carroll, Thomas J.; Das, Amrita.

In: Organogenesis, Vol. 7, No. 3, 07.2011, p. 180-190.

Research output: Contribution to journalArticle

Carroll, Thomas J. ; Das, Amrita. / Planar cell polarity in kidney development and disease. In: Organogenesis. 2011 ; Vol. 7, No. 3. pp. 180-190.
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