Plasma 24S-hydroxycholesterol and other oxysterols in acute closed head injury

Myron F. Weiner, Gloria L. Vega, Ramon Diaz-Arrastia, Carol Moore, Christopher Madden, Anne Hudak, Dieter Lutjohann

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Primary objective: To determine if plasma levels of 24S-hydroxycholesterol, the primary catabolite of brain cholesterol, provide a measure of axonal damage in acute brain trauma. Research design: Determination of plasma 24S-hydroxycholesterol in a series of persons admitted to an intensive care unit for treatment of closed head injury. Methods and procedures: Levels of 24-S-hydroxycholesterol, 27-hydroxycholesterol, lathosterol and total cholesterol were measured in peripheral blood from 38 persons from 14-55 years of age treated by craniotomy and ventriculostomy for intractable intracerebral hypertension. Severity of brain injury was estimated by the Glasgow Coma Scale (range = 3-13, median = 6 points) and overall injury by the Injury Severity Scale (range = 10-48, median = 29). All subjects were intubated and anaesthetized with intravenous propofol. Plasma sterol levels were compared with those of age-matched control subjects. Outcomes and results: There was no significant increase in plasma 24-S-hydroxycholesterol in subjects with head injury, but measures of peripheral cholesterol synthesis were markedly reduced as compared with values for age-matched normal control subjects. Conclusion: Plasma 24S-hydroxycholesterol levels do not change with severe closed head injury.

Original languageEnglish (US)
Pages (from-to)611-615
Number of pages5
JournalBrain injury
Volume22
Issue number7-8
DOIs
StatePublished - Jul 2008

Keywords

  • 24-S-hydroxycholesterol
  • Closed head injury
  • Oxysterols

ASJC Scopus subject areas

  • Neuroscience (miscellaneous)
  • Developmental and Educational Psychology
  • Clinical Neurology

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