Plasma ACTH levels in the human fetus and neonate as related to age and parturition

A. J. Winters, C. Oliver, C. Colston, P. C. MacDonald, J. C. Porter

Research output: Contribution to journalArticle

129 Citations (Scopus)

Abstract

ACTH levels were measured by radioimmunoassay in umbilical cord plasma from fetuses, in capillary plasma from neonates, and in venous plasma from adults. Cord plasma was obtained from term fetuses delivered under the following four conditions: vaginally after spontaneous labor, by cesarean section after spontaneous labor, by cesarean section before spontaneous labor, and vaginally after oxytocin induced labor. The ACTH values in these 4 groups of term fetuses did not differ significantly. Thus, human umbilical cord ACTH does not rise with spontaneous labor. The concentration of ACTH in cord plasma prior to the 34th gestational wk was 241 ± 33 pg/ml (mean and SE); and in term fetuses, the ACTH levels were 143 ± 7 pg/ml. In infants during the first wk of life, the ACTH concentration was 120 ± 8 pg/ml. The mean ACTH level in all fetuses was higher than the afternoon values in normal adults (43 ± 4 pg/ml). These results suggest that an increased ACTH concentration in fetal plasma is not essential for the initiation of labor in the human.

Original languageEnglish (US)
Pages (from-to)269-273
Number of pages5
JournalJournal of Clinical Endocrinology and Metabolism
Volume39
Issue number2
StatePublished - 1974

Fingerprint

Adrenocorticotropic Hormone
Fetus
Parturition
Newborn Infant
Plasmas
Personnel
Umbilical Cord
Cesarean Section
Induced Labor
Oxytocin
Radioimmunoassay
Reference Values

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

Cite this

Winters, A. J., Oliver, C., Colston, C., MacDonald, P. C., & Porter, J. C. (1974). Plasma ACTH levels in the human fetus and neonate as related to age and parturition. Journal of Clinical Endocrinology and Metabolism, 39(2), 269-273.

Plasma ACTH levels in the human fetus and neonate as related to age and parturition. / Winters, A. J.; Oliver, C.; Colston, C.; MacDonald, P. C.; Porter, J. C.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 39, No. 2, 1974, p. 269-273.

Research output: Contribution to journalArticle

Winters, AJ, Oliver, C, Colston, C, MacDonald, PC & Porter, JC 1974, 'Plasma ACTH levels in the human fetus and neonate as related to age and parturition', Journal of Clinical Endocrinology and Metabolism, vol. 39, no. 2, pp. 269-273.
Winters, A. J. ; Oliver, C. ; Colston, C. ; MacDonald, P. C. ; Porter, J. C. / Plasma ACTH levels in the human fetus and neonate as related to age and parturition. In: Journal of Clinical Endocrinology and Metabolism. 1974 ; Vol. 39, No. 2. pp. 269-273.
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