Plasma and aqueous humor endothelin levels in primary open-angle glaucoma

Gülgün Tezel, Michael A. Kass, Allan E. Kolker, Bernard Becker, Martin B. Wax

Research output: Contribution to journalArticle

151 Scopus citations

Abstract

Purpose: Endothelins (ET) have some effects on the regulation of aqueous humor dynamics. To investigate their possible role in glaucoma, we measured plasma and aqueous humor ET levels in patients with and without primary open-angle glaucoma. Methods: Plasma and aqueous humor samples were obtained from 31 patients with primary open-angle glaucoma and 24 patients without glaucoma. Measurements were made by radioimmunoassay (RIA) for ETs with the following cross-reactivities: ET-1, ET-2, and big ET-1, 100%; and ET-3, 70%. Results: The ages (mean ± SD) of the patients with primary open-angle glaucoma (72.3 ± 10 years) and normal subjects (72.8 ± 8 years) were similar (p = 0.92). There was no significant difference between plasma ET levels of the two groups (p = 0.07). However, aqueous humor ET levels (mean ± SD) were higher in the primary open-angle glaucoma group (44.26 ± 2.6 pg ml-1) than in normal subjects (42.17 ± 1.6 pg ml-1) (p = 0.001). The ratios of corresponding aqueous humor to plasma levels of ETs were ~ 10% higher in the primary open-angle glaucoma group (3.76) than in normal subjects (3.41) (p = 0.0002). Conclusions: The small increase in aqueous humor endothelin levels in patients with primary open-angle glaucoma versus controls of similar age may be relevant to the understanding of the various roles of ETs in aqueous humor dynamics in these patients.

Original languageEnglish (US)
Pages (from-to)83-89
Number of pages7
JournalJournal of Glaucoma
Volume6
Issue number2
Publication statusPublished - Apr 1997

    Fingerprint

Keywords

  • Aqueous humor
  • Endothelin
  • Primary open-angle glaucoma

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Tezel, G., Kass, M. A., Kolker, A. E., Becker, B., & Wax, M. B. (1997). Plasma and aqueous humor endothelin levels in primary open-angle glaucoma. Journal of Glaucoma, 6(2), 83-89.