TY - JOUR
T1 - Plasma cholinesterase activity and tachyphylaxis during prolonged succinylcholine infusion
AU - Delisle, S.
AU - Lebrun, M.
AU - Bevan, D.
PY - 1982
Y1 - 1982
N2 - Fifteen patients were studied during general anesthesia (nitrous oxide-fentanyl, N = 7 or nitrous oxide-isoflurane, N = 8) to determine the relationship between plasma cholinesterase activity and succinylcholine requirements during prolonged infusion. Using train-of-four stimulation, neuromuscular block was maintained at 90% for at least 1 hour, and plasma cholinesterase was measured at 30-minute intervals. During the infusion, succinylcholine requirements increased in every patient (tachyphylaxis), but there was no significant change in plasma cholinesterase activity. Succinylcholine requirements during the 1st hour of infusion in patients given fentanyl were correlated with preinfusion cholinesterase activity. It is concluded that tachyphylaxis to succinylcholine is not the result of increased metabolism from enzyme induction and that succinylcholine requirement is related to plasma cholinesterase activity.
AB - Fifteen patients were studied during general anesthesia (nitrous oxide-fentanyl, N = 7 or nitrous oxide-isoflurane, N = 8) to determine the relationship between plasma cholinesterase activity and succinylcholine requirements during prolonged infusion. Using train-of-four stimulation, neuromuscular block was maintained at 90% for at least 1 hour, and plasma cholinesterase was measured at 30-minute intervals. During the infusion, succinylcholine requirements increased in every patient (tachyphylaxis), but there was no significant change in plasma cholinesterase activity. Succinylcholine requirements during the 1st hour of infusion in patients given fentanyl were correlated with preinfusion cholinesterase activity. It is concluded that tachyphylaxis to succinylcholine is not the result of increased metabolism from enzyme induction and that succinylcholine requirement is related to plasma cholinesterase activity.
UR - http://www.scopus.com/inward/record.url?scp=0019982147&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0019982147&partnerID=8YFLogxK
U2 - 10.1213/00000539-198211000-00010
DO - 10.1213/00000539-198211000-00010
M3 - Article
C2 - 7137612
AN - SCOPUS:0019982147
SN - 0003-2999
VL - 61
SP - 941
EP - 944
JO - Anesthesia and analgesia
JF - Anesthesia and analgesia
IS - 11
ER -