Plasma exchange in neuroimmunological disorders: Part 1: Rationale and treatment of inflammatory central nervous system disorders

Helmar C. Lehmann, Hans Peter Hartung, Gerd R. Hetzel, Olaf Stüve, Bernd C. Kieseier

Research output: Contribution to journalReview article

95 Scopus citations

Abstract

Plasma exchange is a well-established therapeutic procedure commonly used in many neurological disorders of autoimmune etiology. It is thought that the beneficial effects of plasma exchange occur through the elimination of pathognomonic inflammatory mediators, including autoantibodies, complement components, and cytokines. In various neurological disorders, randomized controlled studies have demonstrated the efficacy of plasma exchange (eg, in Guillain-Barré syndrome and other forms of immune neuropathies). Although widely used, the potential benefit of plasma exchange in the treatment of multiple sclerosis, myasthenia gravis, and Lambert-Eaton syndrome is less clear.

Original languageEnglish (US)
Pages (from-to)930-935
Number of pages6
JournalArchives of neurology
Volume63
Issue number7
DOIs
StatePublished - Jul 17 2006

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Clinical Neurology

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