Plasma exchange in neuroimmunological disorders: Part 1: Rationale and treatment of inflammatory central nervous system disorders

Helmar C. Lehmann, Hans Peter Hartung, Gerd R. Hetzel, Olaf Stüve, Bernd C. Kieseier

Research output: Contribution to journalArticle

90 Citations (Scopus)

Abstract

Plasma exchange is a well-established therapeutic procedure commonly used in many neurological disorders of autoimmune etiology. It is thought that the beneficial effects of plasma exchange occur through the elimination of pathognomonic inflammatory mediators, including autoantibodies, complement components, and cytokines. In various neurological disorders, randomized controlled studies have demonstrated the efficacy of plasma exchange (eg, in Guillain-Barré syndrome and other forms of immune neuropathies). Although widely used, the potential benefit of plasma exchange in the treatment of multiple sclerosis, myasthenia gravis, and Lambert-Eaton syndrome is less clear.

Original languageEnglish (US)
Pages (from-to)930-935
Number of pages6
JournalArchives of Neurology
Volume63
Issue number7
DOIs
StatePublished - 2006

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Plasma Exchange
Central Nervous System Diseases
Nervous System Diseases
Lambert-Eaton Myasthenic Syndrome
Myasthenia Gravis
Therapeutics
Autoantibodies
Multiple Sclerosis
Cytokines
Central Nervous System
Plasma
Syndrome
Neurological Disorders

ASJC Scopus subject areas

  • Neuroscience(all)

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Plasma exchange in neuroimmunological disorders : Part 1: Rationale and treatment of inflammatory central nervous system disorders. / Lehmann, Helmar C.; Hartung, Hans Peter; Hetzel, Gerd R.; Stüve, Olaf; Kieseier, Bernd C.

In: Archives of Neurology, Vol. 63, No. 7, 2006, p. 930-935.

Research output: Contribution to journalArticle

Lehmann, Helmar C. ; Hartung, Hans Peter ; Hetzel, Gerd R. ; Stüve, Olaf ; Kieseier, Bernd C. / Plasma exchange in neuroimmunological disorders : Part 1: Rationale and treatment of inflammatory central nervous system disorders. In: Archives of Neurology. 2006 ; Vol. 63, No. 7. pp. 930-935.
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