TY - JOUR
T1 - Plasma exchange in neuroimmunological disorders
T2 - Part 1: Rationale and treatment of inflammatory central nervous system disorders
AU - Lehmann, Helmar C.
AU - Hartung, Hans Peter
AU - Hetzel, Gerd R.
AU - Stüve, Olaf
AU - Kieseier, Bernd C.
N1 - Copyright:
Copyright 2011 Elsevier B.V., All rights reserved.
PY - 2006
Y1 - 2006
N2 - Plasma exchange is a well-established therapeutic procedure commonly used in many neurological disorders of autoimmune etiology. It is thought that the beneficial effects of plasma exchange occur through the elimination of pathognomonic inflammatory mediators, including autoantibodies, complement components, and cytokines. In various neurological disorders, randomized controlled studies have demonstrated the efficacy of plasma exchange (eg, in Guillain-Barré syndrome and other forms of immune neuropathies). Although widely used, the potential benefit of plasma exchange in the treatment of multiple sclerosis, myasthenia gravis, and Lambert-Eaton syndrome is less clear.
AB - Plasma exchange is a well-established therapeutic procedure commonly used in many neurological disorders of autoimmune etiology. It is thought that the beneficial effects of plasma exchange occur through the elimination of pathognomonic inflammatory mediators, including autoantibodies, complement components, and cytokines. In various neurological disorders, randomized controlled studies have demonstrated the efficacy of plasma exchange (eg, in Guillain-Barré syndrome and other forms of immune neuropathies). Although widely used, the potential benefit of plasma exchange in the treatment of multiple sclerosis, myasthenia gravis, and Lambert-Eaton syndrome is less clear.
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U2 - 10.1001/archneur.63.7.930
DO - 10.1001/archneur.63.7.930
M3 - Review article
C2 - 16831960
AN - SCOPUS:33745809518
SN - 0003-9942
VL - 63
SP - 930
EP - 935
JO - Archives of neurology
JF - Archives of neurology
IS - 7
ER -