Plasma GABA levels correlate with aggressiveness in relatives of patients with unipolar depressive disorder

James M. Bjork, F. Gerard Moeller, Gerald L. Kramer, Martin Kram, Alina Suris, A. John Rush, Frederick Petty

Research output: Contribution to journalArticle

76 Citations (Scopus)

Abstract

Plasma gamma-aminobutyric acid (GABA) levels are decreased in some patients with depression, mania and alcoholism. Medications which increase plasma GABA improve symptoms of mood disorders and can decrease aggression. We examined the relationship between plasma GABA and aggressiveness on the Buss-Durkee Hostility Inventory in 77 psychiatrically healthy adults. In subjects selected for having a first-degree relative with primary unipolar depressive disorder (FH +, n = 33), plasma GABA was negatively correlated with aggressiveness (beta = -0.338, P = 0.036), as was age (beta = -0.483, P = 0.005). A relationship between plasma GABA levels and aggressiveness was not observed in subjects with no such family history (FH-, n = 44). Moreover, FH + subjects had significantly lower plasma GABA concentrations than FH - subjects. These data suggest that low GABA levels may correlate with some aspects of aggressiveness and may be genetically regulated.

Original languageEnglish (US)
Pages (from-to)131-136
Number of pages6
JournalPsychiatry Research
Volume101
Issue number2
DOIs
StatePublished - Mar 25 2001

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Depressive Disorder
gamma-Aminobutyric Acid
Hostility
Aggression
Mood Disorders
Bipolar Disorder
Alcoholism
Depression
Equipment and Supplies

Keywords

  • Aggression
  • Biological markers
  • GABA
  • Hostility

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry
  • Psychology(all)

Cite this

Bjork, J. M., Moeller, F. G., Kramer, G. L., Kram, M., Suris, A., Rush, A. J., & Petty, F. (2001). Plasma GABA levels correlate with aggressiveness in relatives of patients with unipolar depressive disorder. Psychiatry Research, 101(2), 131-136. https://doi.org/10.1016/S0165-1781(01)00220-7

Plasma GABA levels correlate with aggressiveness in relatives of patients with unipolar depressive disorder. / Bjork, James M.; Moeller, F. Gerard; Kramer, Gerald L.; Kram, Martin; Suris, Alina; Rush, A. John; Petty, Frederick.

In: Psychiatry Research, Vol. 101, No. 2, 25.03.2001, p. 131-136.

Research output: Contribution to journalArticle

Bjork, JM, Moeller, FG, Kramer, GL, Kram, M, Suris, A, Rush, AJ & Petty, F 2001, 'Plasma GABA levels correlate with aggressiveness in relatives of patients with unipolar depressive disorder', Psychiatry Research, vol. 101, no. 2, pp. 131-136. https://doi.org/10.1016/S0165-1781(01)00220-7
Bjork, James M. ; Moeller, F. Gerard ; Kramer, Gerald L. ; Kram, Martin ; Suris, Alina ; Rush, A. John ; Petty, Frederick. / Plasma GABA levels correlate with aggressiveness in relatives of patients with unipolar depressive disorder. In: Psychiatry Research. 2001 ; Vol. 101, No. 2. pp. 131-136.
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