Plasma glucagon levels during rapid exsanguination with and without adrenergic blockade

C. A. Lindsey, G. R. Faloona, Roger H Unger

Research output: Contribution to journalArticle

32 Scopus citations

Abstract

In eleven dogs made hypotensive by means of rapid exsanguination over a period of 40 to 70 min, mean glucagon rose to a peak of 516 ± (S.E.) 150 pg/ml and mean glucose to a peak of 341 ± 27 mg per 100 ml. The hyperglucagonemia induced by exsanguination was substantially reduced, although not abolished, by propranolol infusion, but was not diminished by phentolamine, suggesting that it was largely a β adrenergic effect. Its possible contribution to survival during shock is considered.

Original languageEnglish (US)
Pages (from-to)313-316
Number of pages4
JournalDiabetes
Volume24
Issue number4
StatePublished - Dec 1 1975

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

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