Plasma glucagon levels during rapid exsanguination with and without adrenergic blockade

C. A. Lindsey, G. R. Faloona, Roger H Unger

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

In eleven dogs made hypotensive by means of rapid exsanguination over a period of 40 to 70 min, mean glucagon rose to a peak of 516 ± (S.E.) 150 pg/ml and mean glucose to a peak of 341 ± 27 mg per 100 ml. The hyperglucagonemia induced by exsanguination was substantially reduced, although not abolished, by propranolol infusion, but was not diminished by phentolamine, suggesting that it was largely a β adrenergic effect. Its possible contribution to survival during shock is considered.

Original languageEnglish (US)
Pages (from-to)313-316
Number of pages4
JournalDiabetes
Volume24
Issue number4
StatePublished - 1975

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Exsanguination
Glucagon
Adrenergic Agents
Phentolamine
Propranolol
Shock
Dogs
Glucose

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Internal Medicine

Cite this

Plasma glucagon levels during rapid exsanguination with and without adrenergic blockade. / Lindsey, C. A.; Faloona, G. R.; Unger, Roger H.

In: Diabetes, Vol. 24, No. 4, 1975, p. 313-316.

Research output: Contribution to journalArticle

Lindsey, C. A. ; Faloona, G. R. ; Unger, Roger H. / Plasma glucagon levels during rapid exsanguination with and without adrenergic blockade. In: Diabetes. 1975 ; Vol. 24, No. 4. pp. 313-316.
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