Abstract
The secretion rate and plasma concentration of the adrenocortical steroid cortisol is modified in subjects treated with estrogenic and/or progestational steroids. The effects of contraceptive steroids on the secretion of ACTH are poorly documented, however. In the current investigation, we found that concentrations of ACTH and cortisol in plasma obtained at 0800-0900 h from a group of women with normal cyclic menses (n = 4) ranged from 78-120 pg/ml and 77-137 ng/ml, respectively. Although significant cyclic changes in the plasma levels of LH, FSH, 17β-estradiol, and progesterone occurred during the ovarian cycle, no obvious cyclic fluctuations in plasma levels of ACTH or cortisol were observed. In women treated with Norinyl 1 + 80 (1.0 mg norethindrone plus 0.08 mg mestranol), plasma concentrations of LH, FSH, 17β-estradiol, and progesterone were significantly lower (P < 0.001) than plasma levels of these hormones in normal women during the ovarian cycle. The mean daily plasma concentrations of ACTH were significantly lower (P < 0.001), whereas plasma cortisol levels were significantly higher (P < 0.001) in women treated with oral contraceptive steroids compared to the levels of these hormones in the untreated ovulatory women.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 346-349 |
| Number of pages | 4 |
| Journal | Journal of Clinical Endocrinology and Metabolism |
| Volume | 49 |
| Issue number | 3 |
| State | Published - 1979 |
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ASJC Scopus subject areas
- Biochemistry
- Endocrinology, Diabetes and Metabolism
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Plasma levels of adrenocorticotropin and cortisol in women receiving oral contraceptive steroid treatment. / Carr, B. R.; Parker, C. R.; Madden, J. D.; MacDonald, P. C.; Porter, J. C.
In: Journal of Clinical Endocrinology and Metabolism, Vol. 49, No. 3, 1979, p. 346-349.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Plasma levels of adrenocorticotropin and cortisol in women receiving oral contraceptive steroid treatment
AU - Carr, B. R.
AU - Parker, C. R.
AU - Madden, J. D.
AU - MacDonald, P. C.
AU - Porter, J. C.
PY - 1979
Y1 - 1979
N2 - The secretion rate and plasma concentration of the adrenocortical steroid cortisol is modified in subjects treated with estrogenic and/or progestational steroids. The effects of contraceptive steroids on the secretion of ACTH are poorly documented, however. In the current investigation, we found that concentrations of ACTH and cortisol in plasma obtained at 0800-0900 h from a group of women with normal cyclic menses (n = 4) ranged from 78-120 pg/ml and 77-137 ng/ml, respectively. Although significant cyclic changes in the plasma levels of LH, FSH, 17β-estradiol, and progesterone occurred during the ovarian cycle, no obvious cyclic fluctuations in plasma levels of ACTH or cortisol were observed. In women treated with Norinyl 1 + 80 (1.0 mg norethindrone plus 0.08 mg mestranol), plasma concentrations of LH, FSH, 17β-estradiol, and progesterone were significantly lower (P < 0.001) than plasma levels of these hormones in normal women during the ovarian cycle. The mean daily plasma concentrations of ACTH were significantly lower (P < 0.001), whereas plasma cortisol levels were significantly higher (P < 0.001) in women treated with oral contraceptive steroids compared to the levels of these hormones in the untreated ovulatory women.
AB - The secretion rate and plasma concentration of the adrenocortical steroid cortisol is modified in subjects treated with estrogenic and/or progestational steroids. The effects of contraceptive steroids on the secretion of ACTH are poorly documented, however. In the current investigation, we found that concentrations of ACTH and cortisol in plasma obtained at 0800-0900 h from a group of women with normal cyclic menses (n = 4) ranged from 78-120 pg/ml and 77-137 ng/ml, respectively. Although significant cyclic changes in the plasma levels of LH, FSH, 17β-estradiol, and progesterone occurred during the ovarian cycle, no obvious cyclic fluctuations in plasma levels of ACTH or cortisol were observed. In women treated with Norinyl 1 + 80 (1.0 mg norethindrone plus 0.08 mg mestranol), plasma concentrations of LH, FSH, 17β-estradiol, and progesterone were significantly lower (P < 0.001) than plasma levels of these hormones in normal women during the ovarian cycle. The mean daily plasma concentrations of ACTH were significantly lower (P < 0.001), whereas plasma cortisol levels were significantly higher (P < 0.001) in women treated with oral contraceptive steroids compared to the levels of these hormones in the untreated ovulatory women.
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M3 - Article
C2 - 224073
AN - SCOPUS:0018616352
VL - 49
SP - 346
EP - 349
JO - Journal of Clinical Endocrinology and Metabolism
JF - Journal of Clinical Endocrinology and Metabolism
SN - 0021-972X
IS - 3
ER -