Plasma levels of adrenocorticotropin and cortisol in women receiving oral contraceptive steroid treatment

B. R. Carr, C. R. Parker, J. D. Madden, P. C. MacDonald, J. C. Porter

Research output: Contribution to journalArticle

61 Citations (Scopus)

Abstract

The secretion rate and plasma concentration of the adrenocortical steroid cortisol is modified in subjects treated with estrogenic and/or progestational steroids. The effects of contraceptive steroids on the secretion of ACTH are poorly documented, however. In the current investigation, we found that concentrations of ACTH and cortisol in plasma obtained at 0800-0900 h from a group of women with normal cyclic menses (n = 4) ranged from 78-120 pg/ml and 77-137 ng/ml, respectively. Although significant cyclic changes in the plasma levels of LH, FSH, 17β-estradiol, and progesterone occurred during the ovarian cycle, no obvious cyclic fluctuations in plasma levels of ACTH or cortisol were observed. In women treated with Norinyl 1 + 80 (1.0 mg norethindrone plus 0.08 mg mestranol), plasma concentrations of LH, FSH, 17β-estradiol, and progesterone were significantly lower (P < 0.001) than plasma levels of these hormones in normal women during the ovarian cycle. The mean daily plasma concentrations of ACTH were significantly lower (P < 0.001), whereas plasma cortisol levels were significantly higher (P < 0.001) in women treated with oral contraceptive steroids compared to the levels of these hormones in the untreated ovulatory women.

Original languageEnglish (US)
Pages (from-to)346-349
Number of pages4
JournalJournal of Clinical Endocrinology and Metabolism
Volume49
Issue number3
StatePublished - 1979

Fingerprint

Oral Contraceptives
Adrenocorticotropic Hormone
Hydrocortisone
Steroids
Plasmas
Therapeutics
Menstrual Cycle
Progesterone
Estradiol
Mestranol
Hormones
Norethindrone
Menstruation
Contraceptive Agents

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

Cite this

Plasma levels of adrenocorticotropin and cortisol in women receiving oral contraceptive steroid treatment. / Carr, B. R.; Parker, C. R.; Madden, J. D.; MacDonald, P. C.; Porter, J. C.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 49, No. 3, 1979, p. 346-349.

Research output: Contribution to journalArticle

Carr, B. R. ; Parker, C. R. ; Madden, J. D. ; MacDonald, P. C. ; Porter, J. C. / Plasma levels of adrenocorticotropin and cortisol in women receiving oral contraceptive steroid treatment. In: Journal of Clinical Endocrinology and Metabolism. 1979 ; Vol. 49, No. 3. pp. 346-349.
@article{b79e020317ab4a0e89a0e1c8899de13f,
title = "Plasma levels of adrenocorticotropin and cortisol in women receiving oral contraceptive steroid treatment",
abstract = "The secretion rate and plasma concentration of the adrenocortical steroid cortisol is modified in subjects treated with estrogenic and/or progestational steroids. The effects of contraceptive steroids on the secretion of ACTH are poorly documented, however. In the current investigation, we found that concentrations of ACTH and cortisol in plasma obtained at 0800-0900 h from a group of women with normal cyclic menses (n = 4) ranged from 78-120 pg/ml and 77-137 ng/ml, respectively. Although significant cyclic changes in the plasma levels of LH, FSH, 17β-estradiol, and progesterone occurred during the ovarian cycle, no obvious cyclic fluctuations in plasma levels of ACTH or cortisol were observed. In women treated with Norinyl 1 + 80 (1.0 mg norethindrone plus 0.08 mg mestranol), plasma concentrations of LH, FSH, 17β-estradiol, and progesterone were significantly lower (P < 0.001) than plasma levels of these hormones in normal women during the ovarian cycle. The mean daily plasma concentrations of ACTH were significantly lower (P < 0.001), whereas plasma cortisol levels were significantly higher (P < 0.001) in women treated with oral contraceptive steroids compared to the levels of these hormones in the untreated ovulatory women.",
author = "Carr, {B. R.} and Parker, {C. R.} and Madden, {J. D.} and MacDonald, {P. C.} and Porter, {J. C.}",
year = "1979",
language = "English (US)",
volume = "49",
pages = "346--349",
journal = "Journal of Clinical Endocrinology and Metabolism",
issn = "0021-972X",
publisher = "The Endocrine Society",
number = "3",

}

TY - JOUR

T1 - Plasma levels of adrenocorticotropin and cortisol in women receiving oral contraceptive steroid treatment

AU - Carr, B. R.

AU - Parker, C. R.

AU - Madden, J. D.

AU - MacDonald, P. C.

AU - Porter, J. C.

PY - 1979

Y1 - 1979

N2 - The secretion rate and plasma concentration of the adrenocortical steroid cortisol is modified in subjects treated with estrogenic and/or progestational steroids. The effects of contraceptive steroids on the secretion of ACTH are poorly documented, however. In the current investigation, we found that concentrations of ACTH and cortisol in plasma obtained at 0800-0900 h from a group of women with normal cyclic menses (n = 4) ranged from 78-120 pg/ml and 77-137 ng/ml, respectively. Although significant cyclic changes in the plasma levels of LH, FSH, 17β-estradiol, and progesterone occurred during the ovarian cycle, no obvious cyclic fluctuations in plasma levels of ACTH or cortisol were observed. In women treated with Norinyl 1 + 80 (1.0 mg norethindrone plus 0.08 mg mestranol), plasma concentrations of LH, FSH, 17β-estradiol, and progesterone were significantly lower (P < 0.001) than plasma levels of these hormones in normal women during the ovarian cycle. The mean daily plasma concentrations of ACTH were significantly lower (P < 0.001), whereas plasma cortisol levels were significantly higher (P < 0.001) in women treated with oral contraceptive steroids compared to the levels of these hormones in the untreated ovulatory women.

AB - The secretion rate and plasma concentration of the adrenocortical steroid cortisol is modified in subjects treated with estrogenic and/or progestational steroids. The effects of contraceptive steroids on the secretion of ACTH are poorly documented, however. In the current investigation, we found that concentrations of ACTH and cortisol in plasma obtained at 0800-0900 h from a group of women with normal cyclic menses (n = 4) ranged from 78-120 pg/ml and 77-137 ng/ml, respectively. Although significant cyclic changes in the plasma levels of LH, FSH, 17β-estradiol, and progesterone occurred during the ovarian cycle, no obvious cyclic fluctuations in plasma levels of ACTH or cortisol were observed. In women treated with Norinyl 1 + 80 (1.0 mg norethindrone plus 0.08 mg mestranol), plasma concentrations of LH, FSH, 17β-estradiol, and progesterone were significantly lower (P < 0.001) than plasma levels of these hormones in normal women during the ovarian cycle. The mean daily plasma concentrations of ACTH were significantly lower (P < 0.001), whereas plasma cortisol levels were significantly higher (P < 0.001) in women treated with oral contraceptive steroids compared to the levels of these hormones in the untreated ovulatory women.

UR - http://www.scopus.com/inward/record.url?scp=0018616352&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0018616352&partnerID=8YFLogxK

M3 - Article

VL - 49

SP - 346

EP - 349

JO - Journal of Clinical Endocrinology and Metabolism

JF - Journal of Clinical Endocrinology and Metabolism

SN - 0021-972X

IS - 3

ER -