Plasma levels of platelet and vascular prostaglandin derivatives in children with sickle cell anaemia

G. R. Buchanan, C. A. Holtkamp

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Platelet and vascular endothelial prostaglandin derivatives were measured by radioimmunoassay in the plasma of 39 children with homozygous sickle cell anaemia and 27 control subjects. The levels of both thromboxane B2 and 6-keto-PGF(1α), the stable end-products of platelet and vascular prostaglandin metabolism, were significantly (p<0.001) greater in sickle cell anaemia plasma than in the plasma of the controls. There were no differences in levels of either 6-keto-PGF(1α) or thromboxane B2 between steady state and vaso-occlusive crisis in the sickle cell patients. Injury to the endothelial lining of blood vessels may occur in sickle cell anaemia as a consequence of contact with the abnormal erythrocytes.

Original languageEnglish (US)
Pages (from-to)394-396
Number of pages3
JournalThrombosis and Haemostasis
Volume54
Issue number2
StatePublished - Dec 1 1985

ASJC Scopus subject areas

  • Hematology

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