TY - JOUR
T1 - Plasma osteopontin is an independent prognostic marker for head and neck cancers
AU - Petrik, David
AU - Lavori, Philip W.
AU - Cao, Hongbin
AU - Zhu, Yonghua
AU - Wong, Priscilla
AU - Christofferson, Erin
AU - Kaplan, Michael J.
AU - Pinto, Harlan A.
AU - Sutphin, Patrick
AU - Koong, Albert C.
AU - Giaccia, Amato J.
AU - Le, Quynh Thu
PY - 2006/11/20
Y1 - 2006/11/20
N2 - Purpose: To confirm the relationship between plasma osteopontin (OPN) levels and treatment outcomes in head and neck squamous cell carcinoma (HNSCC) patients in an expanded study. Patients and Methods: One hundred forty patients with newly diagnosed HNSCC were enrolled onto this study, 54 previously reported and 86 new patients. Pretreatment plasma OPN levels were assessed in all patients by an enzyme-linked immunosorbent assay method. OPN levels were correlated to treatment outcomes in the new group of patients. Detailed analyses were also performed on the relationship between OPN and tumor control rate, event-free survival (EFS), and postrelapse survival for the entire group. Results: Using a previously defined cut off point of 450 ng/mL, there was a significant correlation between OPN and freedom-from-relapse (P = .047), overall survival (P = .019), and EFS (P = .023) in the new, independent patient cohort (n = 86). Sequence of event analyses using the entire group (N = 140) revealed that OPN was an independent prognostic factor for initial tumor control, EFS in those who have achieved tumor control, and postrelapse survival. Conclusion: In this expanded study, we were able to replicate the prognostic significance of OPN using a predefined cut off point in an independent patient group and demonstrated that plasma OPN is an independent prognostic marker for HNSCC.
AB - Purpose: To confirm the relationship between plasma osteopontin (OPN) levels and treatment outcomes in head and neck squamous cell carcinoma (HNSCC) patients in an expanded study. Patients and Methods: One hundred forty patients with newly diagnosed HNSCC were enrolled onto this study, 54 previously reported and 86 new patients. Pretreatment plasma OPN levels were assessed in all patients by an enzyme-linked immunosorbent assay method. OPN levels were correlated to treatment outcomes in the new group of patients. Detailed analyses were also performed on the relationship between OPN and tumor control rate, event-free survival (EFS), and postrelapse survival for the entire group. Results: Using a previously defined cut off point of 450 ng/mL, there was a significant correlation between OPN and freedom-from-relapse (P = .047), overall survival (P = .019), and EFS (P = .023) in the new, independent patient cohort (n = 86). Sequence of event analyses using the entire group (N = 140) revealed that OPN was an independent prognostic factor for initial tumor control, EFS in those who have achieved tumor control, and postrelapse survival. Conclusion: In this expanded study, we were able to replicate the prognostic significance of OPN using a predefined cut off point in an independent patient group and demonstrated that plasma OPN is an independent prognostic marker for HNSCC.
UR - http://www.scopus.com/inward/record.url?scp=34247346481&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=34247346481&partnerID=8YFLogxK
U2 - 10.1200/JCO.2006.06.8627
DO - 10.1200/JCO.2006.06.8627
M3 - Article
C2 - 17114663
AN - SCOPUS:34247346481
SN - 0732-183X
VL - 24
SP - 5291
EP - 5297
JO - Journal of Clinical Oncology
JF - Journal of Clinical Oncology
IS - 33
ER -