PLASMA PROPRANOLOL CONCENTRATION IN PATIENTS WITH ANGINA AND ACUTE MYOCARDIAL INFARCTION

J. D. Rutherford, B. N. Singh, P. K. Ambler, R. M. Norris

Research output: Contribution to journalArticle

22 Scopus citations

Abstract

1. Plasma levels of propranolol were measured fluorometrically in patients with angina pectoris and in patients admitted to the Coronary Care Unit with acute myocardial infarction. 2. In thirty patients with stable angina pectoris, plasma propranolol levels varied almost linearly with doses between 10 and 120 mg during 6‐hourly chronic oral administration. Plasma levels greater than 100 ng/ml produced 70–80% reduction in the tachycardia induced by strenous exercise on a treadmill. 3. In nineteen patients with acute myocardial infarction given oral propranolol, 20 mg 6‐hourly, peak as well as trough plasma levels of the drug increased progressively but remained below 100 ng/ml in all except two patients during the first 24 h after their admission to the Coronary Care Unit. 4. The data suggest that the use of low and fixed doses of propranolol may not produce adequate plasma levels or significant β‐adrenoceptor blockade in the early stages of acute myocardial infarction in man.

Original languageEnglish (US)
Pages (from-to)297-304
Number of pages8
JournalClinical and Experimental Pharmacology and Physiology
Volume3
Issue number4
DOIs
StatePublished - Aug 1976

Keywords

  • exercise‐induced tachycardia
  • myocardial infarction
  • plasma propranolol levels.
  • β‐adrenoceptor blockade

ASJC Scopus subject areas

  • Physiology
  • Pharmacology
  • Physiology (medical)

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