Abstract
The possible relation between prostaglandin production and the sensitivity of pregnant women with pregnancy-induced hypertension to the pressor effects of angiotensin II was investigated. Plasma prostaglandin levels were determined in four groups of women before, during, and after intravenous infusion of angiotensin II. Concentrations of the stable metabolites of prostaglandin E2, prostaglandin F2α, and prostaglandin I2 (prostacyclin) were quantified by specific radioimmunoassays in the plasma of nonpregnant women, women pregnant in the late third trimester, and women pregnant in the late third trimester with either pregnancy-induced or chronic hypertension. Plasma prostaglandin concentrations did not change significantly during angiotensin II infusion in any of the four groups of women. Levels of the prostacyclin metabolite, however, were significantly higher in the hypertensive pregnant women than in the normotensive pregnant women.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 952-955 |
| Number of pages | 4 |
| Journal | American Journal of Obstetrics and Gynecology |
| Volume | 150 |
| Issue number | 8 |
| DOIs | |
| State | Published - Dec 15 1984 |
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ASJC Scopus subject areas
- Obstetrics and Gynecology
Cite this
Plasma prostaglandins during the intravenous infusion of angiotensin II in pregnant women. / Strickland, Daniel M.; Cox, Kay; McCubbin, Jack H.; Whalley, Peggy J.; MacDonald, Paul C.; Mitchell, Murray D.
In: American Journal of Obstetrics and Gynecology, Vol. 150, No. 8, 15.12.1984, p. 952-955.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Plasma prostaglandins during the intravenous infusion of angiotensin II in pregnant women
AU - Strickland, Daniel M.
AU - Cox, Kay
AU - McCubbin, Jack H.
AU - Whalley, Peggy J.
AU - MacDonald, Paul C.
AU - Mitchell, Murray D.
PY - 1984/12/15
Y1 - 1984/12/15
N2 - The possible relation between prostaglandin production and the sensitivity of pregnant women with pregnancy-induced hypertension to the pressor effects of angiotensin II was investigated. Plasma prostaglandin levels were determined in four groups of women before, during, and after intravenous infusion of angiotensin II. Concentrations of the stable metabolites of prostaglandin E2, prostaglandin F2α, and prostaglandin I2 (prostacyclin) were quantified by specific radioimmunoassays in the plasma of nonpregnant women, women pregnant in the late third trimester, and women pregnant in the late third trimester with either pregnancy-induced or chronic hypertension. Plasma prostaglandin concentrations did not change significantly during angiotensin II infusion in any of the four groups of women. Levels of the prostacyclin metabolite, however, were significantly higher in the hypertensive pregnant women than in the normotensive pregnant women.
AB - The possible relation between prostaglandin production and the sensitivity of pregnant women with pregnancy-induced hypertension to the pressor effects of angiotensin II was investigated. Plasma prostaglandin levels were determined in four groups of women before, during, and after intravenous infusion of angiotensin II. Concentrations of the stable metabolites of prostaglandin E2, prostaglandin F2α, and prostaglandin I2 (prostacyclin) were quantified by specific radioimmunoassays in the plasma of nonpregnant women, women pregnant in the late third trimester, and women pregnant in the late third trimester with either pregnancy-induced or chronic hypertension. Plasma prostaglandin concentrations did not change significantly during angiotensin II infusion in any of the four groups of women. Levels of the prostacyclin metabolite, however, were significantly higher in the hypertensive pregnant women than in the normotensive pregnant women.
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U2 - 10.1016/0002-9378(84)90389-2
DO - 10.1016/0002-9378(84)90389-2
M3 - Article
VL - 150
SP - 952
EP - 955
JO - American Journal of Obstetrics and Gynecology
JF - American Journal of Obstetrics and Gynecology
SN - 0002-9378
IS - 8
ER -