TY - JOUR
T1 - Plasma prostaglandins during the intravenous infusion of angiotensin II in pregnant women
AU - Strickland, Daniel M.
AU - Cox, Kay
AU - McCubbin, Jack H.
AU - Whalley, Peggy J.
AU - MacDonald, Paul C.
AU - Mitchell, Murray D.
N1 - Funding Information:
From the Cecil H. and Ida Green Center for Reproductive Biology Sciences and the Departments of Obstetrics-Gynecology and Bio chemistry, The University of Texas Southwestern Medical School. This study was supported in part by United States Public Health Service Grant No. 5-P50-HD11149. Received for publication November 22, 1983; revised june 4, accepted june 22, 1984. Reprint requests: Murray D. Mitchell, D.Phil., Departments of Obstetrics-Gynecology and Biochemistry, 5323 Harry Hines Blvd., Dallas, TX 75235.
PY - 1984/12/15
Y1 - 1984/12/15
N2 - The possible relation between prostaglandin production and the sensitivity of pregnant women with pregnancy-induced hypertension to the pressor effects of angiotensin II was investigated. Plasma prostaglandin levels were determined in four groups of women before, during, and after intravenous infusion of angiotensin II. Concentrations of the stable metabolites of prostaglandin E2, prostaglandin F2α, and prostaglandin I2 (prostacyclin) were quantified by specific radioimmunoassays in the plasma of nonpregnant women, women pregnant in the late third trimester, and women pregnant in the late third trimester with either pregnancy-induced or chronic hypertension. Plasma prostaglandin concentrations did not change significantly during angiotensin II infusion in any of the four groups of women. Levels of the prostacyclin metabolite, however, were significantly higher in the hypertensive pregnant women than in the normotensive pregnant women.
AB - The possible relation between prostaglandin production and the sensitivity of pregnant women with pregnancy-induced hypertension to the pressor effects of angiotensin II was investigated. Plasma prostaglandin levels were determined in four groups of women before, during, and after intravenous infusion of angiotensin II. Concentrations of the stable metabolites of prostaglandin E2, prostaglandin F2α, and prostaglandin I2 (prostacyclin) were quantified by specific radioimmunoassays in the plasma of nonpregnant women, women pregnant in the late third trimester, and women pregnant in the late third trimester with either pregnancy-induced or chronic hypertension. Plasma prostaglandin concentrations did not change significantly during angiotensin II infusion in any of the four groups of women. Levels of the prostacyclin metabolite, however, were significantly higher in the hypertensive pregnant women than in the normotensive pregnant women.
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U2 - 10.1016/0002-9378(84)90389-2
DO - 10.1016/0002-9378(84)90389-2
M3 - Article
C2 - 6391178
AN - SCOPUS:0021702559
VL - 150
SP - 952
EP - 955
JO - American Journal of Obstetrics and Gynecology
JF - American Journal of Obstetrics and Gynecology
SN - 0002-9378
IS - 8
ER -