TY - JOUR
T1 - Plasma Renin Activity Suppression
T2 - Duration After Withdrawal From β-Adrenergic Blockade
AU - Garrett, B. N.
AU - Kaplan, Norman M
N1 - Copyright:
Copyright 2015 Elsevier B.V., All rights reserved.
PY - 1980/10
Y1 - 1980/10
N2 - β-Blocking drugs suppress plasma renin activity (PRA) promptly. The current study was undertaken to document the return of PRA once blockade is withdrawn. In addition, we have correlated the return of PRA with both fall in plasma propranolol levels and change in blood pressure (BP). Fourteen patients established a baseline PRA. Propranolol hydrochloride, 40 mg twice daily, was given for seven days and withdrawn abruptly. The PRA, plasma propranolol level, and BP were measured one and 12 hours after withdrawal, then every 24 hours. The PRA returns to baseline 12 hours after cessation of therapy. After withdrawal of therapy, there seems to be a “rebound” phenomenon in PRA, with elevations of 70% above baseline. This rebound also is demonstrated by a nonsignificant rise in BP. Plasma propranolol levels fall by 70% within 13 hours of withdrawal. The decrease in propranolol levels closely correlates with the rise in PRA.
AB - β-Blocking drugs suppress plasma renin activity (PRA) promptly. The current study was undertaken to document the return of PRA once blockade is withdrawn. In addition, we have correlated the return of PRA with both fall in plasma propranolol levels and change in blood pressure (BP). Fourteen patients established a baseline PRA. Propranolol hydrochloride, 40 mg twice daily, was given for seven days and withdrawn abruptly. The PRA, plasma propranolol level, and BP were measured one and 12 hours after withdrawal, then every 24 hours. The PRA returns to baseline 12 hours after cessation of therapy. After withdrawal of therapy, there seems to be a “rebound” phenomenon in PRA, with elevations of 70% above baseline. This rebound also is demonstrated by a nonsignificant rise in BP. Plasma propranolol levels fall by 70% within 13 hours of withdrawal. The decrease in propranolol levels closely correlates with the rise in PRA.
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U2 - 10.1001/archinte.1980.00330210064025
DO - 10.1001/archinte.1980.00330210064025
M3 - Article
C2 - 6107071
AN - SCOPUS:0018965355
SN - 0003-9926
VL - 140
SP - 1316
EP - 1318
JO - Archives of Internal Medicine
JF - Archives of Internal Medicine
IS - 10
ER -