TY - JOUR
T1 - Plasma renin and risk of cardiovascular disease and mortality
T2 - The Framingham Heart Study
AU - Parikh, Nisha I.
AU - Gona, Philimon
AU - Larson, Martin G.
AU - Wang, Thomas J.
AU - Newton-Cheh, Christopher
AU - Levy, Daniel
AU - Benjamin, Emelia J.
AU - Kannel, William B.
AU - Vasan, Ramachandran S.
N1 - Funding Information:
Supported by a National Institute of Health/National Heart, Lung, and Blood Institute, contract N01-HC-25195 to Boston University, research grants R01HL67288, 2K24HL04334 to RSV, and K23HL074077 to TJW.
PY - 2007/11
Y1 - 2007/11
N2 - Aims: Previous studies relating plasma renin to cardiovascular disease (CVD) and mortality yielded conflicting results. We related plasma renin to incidence of CVD and mortality in 3408 individuals (mean age 59; 53% women) and in a hypertensive subset (n = 1413). Methods and results: On follow-up (mean 7.1 years), 176 participants (122 hypertensives) developed CVD and 215 individuals (127 hypertensives) died. Overall, log-renin was associated with mortality [multivariable-adjusted hazards ratio (HR) per SD increment: in whole sample, 1.14, 95% confidence interval (CI) 1.00-1.30, P = 0.046; hypertensives, 1.16, 95% CI 1.00-1.35, P = 0.046], but relations varied over time (P < 0.02). Log-renin was associated with mortality at 2.5 years of follow-up (HR per SD increment: whole sample at 2.5 years, 1.23, 95% CI 1.04-1.45; hypertensives at 2 years, 1.28, 95% CI 1.06-1.54), but not during longer follow-up (HR per SD increment at 5 years: whole sample, 1.02, 95% CI 0.80-1.29; hypertensives, 0.98, 95% CI 0.74-1.30). The time-dependent relation of renin and mortality risk was maintained upon excluding participants with prevalent CVD. Renin was not associated with CVD incidence (HR per SD increment log-renin: whole sample, 0.99, 95% CI 0.85-1.14; hypertensives, 0.96, 95% CI 0.82-1.12). Conclusion: Higher plasma renin was associated with greater short-term mortality but not with CVD incidence in the community.
AB - Aims: Previous studies relating plasma renin to cardiovascular disease (CVD) and mortality yielded conflicting results. We related plasma renin to incidence of CVD and mortality in 3408 individuals (mean age 59; 53% women) and in a hypertensive subset (n = 1413). Methods and results: On follow-up (mean 7.1 years), 176 participants (122 hypertensives) developed CVD and 215 individuals (127 hypertensives) died. Overall, log-renin was associated with mortality [multivariable-adjusted hazards ratio (HR) per SD increment: in whole sample, 1.14, 95% confidence interval (CI) 1.00-1.30, P = 0.046; hypertensives, 1.16, 95% CI 1.00-1.35, P = 0.046], but relations varied over time (P < 0.02). Log-renin was associated with mortality at 2.5 years of follow-up (HR per SD increment: whole sample at 2.5 years, 1.23, 95% CI 1.04-1.45; hypertensives at 2 years, 1.28, 95% CI 1.06-1.54), but not during longer follow-up (HR per SD increment at 5 years: whole sample, 1.02, 95% CI 0.80-1.29; hypertensives, 0.98, 95% CI 0.74-1.30). The time-dependent relation of renin and mortality risk was maintained upon excluding participants with prevalent CVD. Renin was not associated with CVD incidence (HR per SD increment log-renin: whole sample, 0.99, 95% CI 0.85-1.14; hypertensives, 0.96, 95% CI 0.82-1.12). Conclusion: Higher plasma renin was associated with greater short-term mortality but not with CVD incidence in the community.
KW - All-cause mortality
KW - Cardiovascular disease
KW - Epidemiology
KW - Hypertension
KW - Renin
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U2 - 10.1093/eurheartj/ehm399
DO - 10.1093/eurheartj/ehm399
M3 - Article
C2 - 17895253
AN - SCOPUS:35948950676
SN - 0195-668X
VL - 28
SP - 2644
EP - 2652
JO - European heart journal
JF - European heart journal
IS - 21
ER -