Plasma somatostatin-like immunoreactivity in chemically sympathectomized dogs

V. Schusdziarra, D. Rouiller, V. Harris, R. Dey, Roger H Unger

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

The present study was designed to determine the role of the adrenergic nerves upon basal and postprandial gastric and pancreatic SLI release. In 19 chemically sympathectomized dogs peripheral venous plasma SLI levels in the basal and postprandial state were significantly below those of 30 controls for the first 135 min after the ingestion of a fat-protein meal. To determine the origin of this reduction, the SLI release from fundus, antrum and pancreas was studied in anesthetized dogs during the gastric phase of a meal at either pH 7 or pH 2. In response to a liver meal at pH 7 fundic, antral and pancreatic vein SLI levels were below the control and the rise in inferior vena cava SLI was abolished. In response to a liver meal at pH 2, the rise in antral and pancreatic vein SLI was clearly reduced in the sympathectomized dogs, while the decrease in fundic SLI was not influenced. The data demonstrate that adrenergic innervation plays a role in basal and postprandial SLI release from the stomach and pancreas.

Original languageEnglish (US)
Pages (from-to)656-660
Number of pages5
JournalHormone and Metabolic Research
Volume12
Issue number12
StatePublished - 1980

Fingerprint

Liver
Adrenergic Agents
Meals
Dogs
Plasmas
Stomach
Pancreas
Veins
Fats
Inferior Vena Cava
Proteins
Eating
somatostatin-like peptides
Antral

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology

Cite this

Plasma somatostatin-like immunoreactivity in chemically sympathectomized dogs. / Schusdziarra, V.; Rouiller, D.; Harris, V.; Dey, R.; Unger, Roger H.

In: Hormone and Metabolic Research, Vol. 12, No. 12, 1980, p. 656-660.

Research output: Contribution to journalArticle

Schusdziarra, V, Rouiller, D, Harris, V, Dey, R & Unger, RH 1980, 'Plasma somatostatin-like immunoreactivity in chemically sympathectomized dogs', Hormone and Metabolic Research, vol. 12, no. 12, pp. 656-660.
Schusdziarra, V. ; Rouiller, D. ; Harris, V. ; Dey, R. ; Unger, Roger H. / Plasma somatostatin-like immunoreactivity in chemically sympathectomized dogs. In: Hormone and Metabolic Research. 1980 ; Vol. 12, No. 12. pp. 656-660.
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