Plasma tumor necrosis factor α predicts decreased long-term survival in severe alcoholic hepatitis

M. E. Felver, E. Mezey, M. McGuire, M. C. Mitchell, H. F. Herlong, G. A. Veech, R. L. Veech

Research output: Contribution to journalArticle

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Abstract

Plasma tumor necrosis factor α (TNF α), interleukin 1 α (IL-1α), and interleukin 1β (IL-1β) were measured in plasma samples obtained from 23 patients with severe alcoholic hepatitis on admission and after 30 days of hospitalization. Over a 2-year follow-up period, 14 patients died at a mean time of 8 months following discharge. The presence of elevated plasma TNF α either at admission or discharge from the hospital was associated with death in 82% (14/17) of patients. By contrast absence of elevated plasma TNF α was associated with survival in 100% (6/6). The difference in survival with and without detectable plasma TNF α was significant at p = 0.0022. Plasma TNF α was not elevated in alcoholic patients without clinically apparent liver disease, with alcoholic cirrhosis, or in nonalcoholic healthy controls. Plasma IL-1α was also significantly increased in alcoholic hepatitis whereas IL-1β was not. Neither IL-1α nor β was correlated with outcome in the alcoholic hepatitis group. It is concluded that the presence of elevated plasma TNF α is a significant predictor of decreased long-term survival in patients with severe alcoholic hepatitis.

Original languageEnglish (US)
Pages (from-to)255-259
Number of pages5
JournalAlcoholism: Clinical and Experimental Research
Volume14
Issue number2
DOIs
StatePublished - 1990

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Alcoholic Hepatitis
Tumor Necrosis Factor-alpha
Plasmas
Interleukin-1
Survival
Alcoholic Liver Cirrhosis
Alcoholics
Liver
Liver Diseases
Hospitalization

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Toxicology

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Plasma tumor necrosis factor α predicts decreased long-term survival in severe alcoholic hepatitis. / Felver, M. E.; Mezey, E.; McGuire, M.; Mitchell, M. C.; Herlong, H. F.; Veech, G. A.; Veech, R. L.

In: Alcoholism: Clinical and Experimental Research, Vol. 14, No. 2, 1990, p. 255-259.

Research output: Contribution to journalArticle

Felver, M. E. ; Mezey, E. ; McGuire, M. ; Mitchell, M. C. ; Herlong, H. F. ; Veech, G. A. ; Veech, R. L. / Plasma tumor necrosis factor α predicts decreased long-term survival in severe alcoholic hepatitis. In: Alcoholism: Clinical and Experimental Research. 1990 ; Vol. 14, No. 2. pp. 255-259.
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