Plasmablastic lymphomas with MYC/IgH rearrangement: Report of three cases and review of the literature

Agata M. Bogusz, Adam C. Seegmiller, Rolando Garcia, Ping Shang, Raheela Ashfaq, Weina Chen

Research output: Contribution to journalArticle

58 Citations (Scopus)

Abstract

We report detailed clinicopathologic features of 3 cases of plasmablastic lymphoma (PBL) with MYC/IgH rearrangement, representing one third of PBL cases diagnosed at our institution. This study brings the total number of reported cases in the literature to 6. All patients were HIV+ with very low CD4 counts at diagnosis. The involved locations were mediastinum, anus, and bone marrow. Tumors exhibited predominantly immunoblastic/plasmablastic morphologic features and had a plasma cell-like immunophenotype. Bright CD38 expression by flow cytometry had a tendency to be more common in these cases compared with PBL without MYC rearrangement. All cases were positive for Epstein-Barr virus-encoded RNA but lacked human herpesvirus-8 latent nuclear antigen. The 2 patients with follow-up died within 3 months. These findings show that PBL is often associated with MYC/IgH rearrangements and that this finding may portend an aggressive clinical course, suggesting that cytogenetic studies should be routinely applied in cases of PBL.

Original languageEnglish (US)
Pages (from-to)597-605
Number of pages9
JournalAmerican Journal of Clinical Pathology
Volume132
Issue number4
DOIs
StatePublished - Oct 2009

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Human Herpesvirus 8
Mediastinum
Anal Canal
CD4 Lymphocyte Count
Plasma Cells
Human Herpesvirus 4
Cytogenetics
Flow Cytometry
Bone Marrow
Plasmablastic Lymphoma
HIV
RNA
Neoplasms
latent nuclear antigen (LNA)

Keywords

  • HIV/AIDS-related lymphomas
  • MYC rearrangement
  • Plasmablastic lymphoma
  • t(8;14)

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Plasmablastic lymphomas with MYC/IgH rearrangement : Report of three cases and review of the literature. / Bogusz, Agata M.; Seegmiller, Adam C.; Garcia, Rolando; Shang, Ping; Ashfaq, Raheela; Chen, Weina.

In: American Journal of Clinical Pathology, Vol. 132, No. 4, 10.2009, p. 597-605.

Research output: Contribution to journalArticle

Bogusz, Agata M. ; Seegmiller, Adam C. ; Garcia, Rolando ; Shang, Ping ; Ashfaq, Raheela ; Chen, Weina. / Plasmablastic lymphomas with MYC/IgH rearrangement : Report of three cases and review of the literature. In: American Journal of Clinical Pathology. 2009 ; Vol. 132, No. 4. pp. 597-605.
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