Abstract
We report detailed clinicopathologic features of 3 cases of plasmablastic lymphoma (PBL) with MYC/IgH rearrangement, representing one third of PBL cases diagnosed at our institution. This study brings the total number of reported cases in the literature to 6. All patients were HIV+ with very low CD4 counts at diagnosis. The involved locations were mediastinum, anus, and bone marrow. Tumors exhibited predominantly immunoblastic/plasmablastic morphologic features and had a plasma cell-like immunophenotype. Bright CD38 expression by flow cytometry had a tendency to be more common in these cases compared with PBL without MYC rearrangement. All cases were positive for Epstein-Barr virus-encoded RNA but lacked human herpesvirus-8 latent nuclear antigen. The 2 patients with follow-up died within 3 months. These findings show that PBL is often associated with MYC/IgH rearrangements and that this finding may portend an aggressive clinical course, suggesting that cytogenetic studies should be routinely applied in cases of PBL.
Original language | English (US) |
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Pages (from-to) | 597-605 |
Number of pages | 9 |
Journal | American journal of clinical pathology |
Volume | 132 |
Issue number | 4 |
DOIs | |
State | Published - Oct 2009 |
Keywords
- HIV/AIDS-related lymphomas
- MYC rearrangement
- Plasmablastic lymphoma
- t(8;14)
ASJC Scopus subject areas
- Pathology and Forensic Medicine