Platelet amyloid precursor protein processing: A bio-marker for Alzheimer's disease

Kun Tang, Linda S. Hynan, Fred Baskin, Roger N. Rosenberg

Research output: Contribution to journalArticle

105 Citations (Scopus)

Abstract

The amyloid precursor protein (APP) in brain is processed either by an amyloidogenic pathway by β-secretase and γ-secretase to yield Aβ (β-amyloid 4 kDa) peptide or by α-secretase within the β-amyloid domain to yield non-amyloidogenic products. We have studied blood platelet levels of a 22-kDa fragment containing the Aβ (β-amyloid 4 kDa) peptide, β-secretase (BACE1), α-secretase (ADAM10), and APP isoform ratios of the 120-130 kDa to 110 kDa peptides from 31 Alzheimer's disease (AD) patients and 10 age-matched healthy control subjects. We found increased levels of Aβ4, increased activation of β-secretase (BACE1), decreased activation of α-secretase (ADAM10) and decreased APP ratios in AD patients compared to normal control subjects. These observations indicate that the blood platelet APP is processed by the same amyloidogenic and non-amyloidogenic pathways as utilized in brain and that APP processing in AD patients is altered compared to control subjects and may be a useful bio-marker for the diagnosis of AD, the progression of disease and for monitoring drug responses in clinical trials.

Original languageEnglish (US)
Pages (from-to)53-58
Number of pages6
JournalJournal of the Neurological Sciences
Volume240
Issue number1-2
DOIs
StatePublished - Jan 15 2006

Fingerprint

Amyloid Precursor Protein Secretases
Amyloid beta-Protein Precursor
Alzheimer Disease
Blood Platelets
Amyloid
Peptides
Drug Monitoring
Brain
Disease Progression
Healthy Volunteers
Protein Isoforms
Clinical Trials

Keywords

  • α-Secretase
  • β-Amyloid
  • β-Secretase
  • Alzheimer's disease
  • APP
  • Platelets

ASJC Scopus subject areas

  • Aging
  • Clinical Neurology
  • Surgery
  • Developmental Neuroscience
  • Neurology
  • Neuroscience(all)

Cite this

Platelet amyloid precursor protein processing : A bio-marker for Alzheimer's disease. / Tang, Kun; Hynan, Linda S.; Baskin, Fred; Rosenberg, Roger N.

In: Journal of the Neurological Sciences, Vol. 240, No. 1-2, 15.01.2006, p. 53-58.

Research output: Contribution to journalArticle

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