Platelet distribution width correlates with prognosis of non-small cell lung cancer

Ming Ming Cui, Na Li, Xing Liu, Zhi Yuan Yun, Ye Niu, Yong Zhang, Boning Gao, Tiemin Liu, Rui Tao Wang

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Abstract

Platelets play a multifaceted role in cancer progression and metastasis. Mean platelet volume (MPV) and platelet distribution width (PDW) are commonly used platelet parameters from routine blood test. The aim of the present study was to investigate the correlation between platelet indices and prognosis in patients with non-small cell lung cancer (NSCLC). A total of 270 patients who were diagnosed with NSCLC between January 2009 and December 2009 were retrospectively analyzed. Patients' characteristics and hematologic tests data at initial diagnosis were collected. The overall survival rate was estimated using Kaplan-Meier method. The prognostic analysis was carried out with univariate and multivariate Cox regressions model. Reduced PDW was significantly correlated with T stage, N stage, TNM stage, and histological type of the disease. Moreover, survival analysis showed that the overall survival of patients with PDW ≥ 16.3% was significantly longer than that of those with PDW < 16.3% (P < 0.001). In multivariate Cox regression model, age, sex, TNM stage, and PDW were identified as independent prognostic factors for overall survival (for PDW, P < 0.001). In conclusion, reduced PDW is an unfavorable predictive factor of NSCLC patient survival. Further studies are warranted.

Original languageEnglish (US)
Article number3456
JournalScientific Reports
Volume7
Issue number1
DOIs
StatePublished - Dec 1 2017

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Non-Small Cell Lung Carcinoma
Blood Platelets
Hematologic Tests
Proportional Hazards Models
Survival
Mean Platelet Volume
Survival Analysis
Survival Rate
Neoplasm Metastasis

ASJC Scopus subject areas

  • General

Cite this

Cui, M. M., Li, N., Liu, X., Yun, Z. Y., Niu, Y., Zhang, Y., ... Wang, R. T. (2017). Platelet distribution width correlates with prognosis of non-small cell lung cancer. Scientific Reports, 7(1), [3456]. https://doi.org/10.1038/s41598-017-03772-z

Platelet distribution width correlates with prognosis of non-small cell lung cancer. / Cui, Ming Ming; Li, Na; Liu, Xing; Yun, Zhi Yuan; Niu, Ye; Zhang, Yong; Gao, Boning; Liu, Tiemin; Wang, Rui Tao.

In: Scientific Reports, Vol. 7, No. 1, 3456, 01.12.2017.

Research output: Contribution to journalArticle

Cui, MM, Li, N, Liu, X, Yun, ZY, Niu, Y, Zhang, Y, Gao, B, Liu, T & Wang, RT 2017, 'Platelet distribution width correlates with prognosis of non-small cell lung cancer', Scientific Reports, vol. 7, no. 1, 3456. https://doi.org/10.1038/s41598-017-03772-z
Cui, Ming Ming ; Li, Na ; Liu, Xing ; Yun, Zhi Yuan ; Niu, Ye ; Zhang, Yong ; Gao, Boning ; Liu, Tiemin ; Wang, Rui Tao. / Platelet distribution width correlates with prognosis of non-small cell lung cancer. In: Scientific Reports. 2017 ; Vol. 7, No. 1.
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