Platelet function in the Chediak Higashi syndrome

G. R. Buchanan, R. I. Handin

Research output: Contribution to journalArticle

71 Citations (Scopus)

Abstract

Platelet function studies were performed on 2 patients with the Chediak Higashi syndrome, one of whom had a history of easy bruising unrelated to thrombocytopenia. Both patients had prolonged bleeding times, abnormal platelet aggregation, and a defect of platelet storage granules, manifested by reduced platelet ADP, an increased ATP/ADP ratio, increased adenine nucleotide specific radioactivity after 3H adenine labeling, and decreased platelet uptake of radioactive 5 hydroxytryptamine. These findings confirm preliminary data in animals with the Chediak Higashi syndrome, provide an explanation for impaired primary hemostasis in these patients, and illustrate another disorder in which platelet storage pool deficiency occurs.

Original languageEnglish (US)
Pages (from-to)941-948
Number of pages8
JournalBlood
Volume47
Issue number6
StatePublished - 1976

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Chediak-Higashi Syndrome
Platelets
Blood Platelets
Adenosine Diphosphate
Platelet Storage Pool Deficiency
Bleeding Time
Adenine Nucleotides
Adenine
Hemostasis
Platelet Aggregation
Thrombocytopenia
Radioactivity
Serotonin
Adenosine Triphosphate
Labeling
Animals
Agglomeration
Defects

ASJC Scopus subject areas

  • Hematology

Cite this

Buchanan, G. R., & Handin, R. I. (1976). Platelet function in the Chediak Higashi syndrome. Blood, 47(6), 941-948.

Platelet function in the Chediak Higashi syndrome. / Buchanan, G. R.; Handin, R. I.

In: Blood, Vol. 47, No. 6, 1976, p. 941-948.

Research output: Contribution to journalArticle

Buchanan, GR & Handin, RI 1976, 'Platelet function in the Chediak Higashi syndrome', Blood, vol. 47, no. 6, pp. 941-948.
Buchanan, G. R. ; Handin, R. I. / Platelet function in the Chediak Higashi syndrome. In: Blood. 1976 ; Vol. 47, No. 6. pp. 941-948.
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