Platelets, coagulation, and the liver

Louise C. Kenny, Keith R. McCrae, F. Gary Cunningham

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Citations (Scopus)

Abstract

This chapter reviews platelets and their function and the coagulation system during normal pregnancy as well as with the preeclampsia syndrome. In addition, the central role of the liver and hepatic dysfunction is described. It has been apparent for almost a century that the coagulation system is in some way involved in the pathogenesis of preeclampsia. Pathological study of specimens taken from the organs of women dying with this disease revealed the presence of fibrin deposition and the formation of thrombi in the microcirculation. Whilst only 10-20% of pregnancies complicated by preeclampsia have evidence of abnormal liver function tests, these pregnancies tend to have a more severe form of the disease. Thus we describe not only the pathophysiology of the hepatic and coagulation cascades in preeclampsia, but the synergistic effect between the two systems that results in the development of HELLP (Hemolysis, Elevated Liver function tests, Low Platelets) syndrome.

Original languageEnglish (US)
Title of host publicationChesley's Hypertensive Disorders in Pregnancy, Fourth Edition
PublisherElsevier Science
Pages379-396
Number of pages18
ISBN (Electronic)9780124078666
DOIs
StatePublished - Jan 1 2014

Fingerprint

Pre-Eclampsia
Blood Platelets
Liver
Liver Function Tests
Pregnancy
Microcirculation
Hemolysis
Fibrin
Liver Diseases
Thrombosis

Keywords

  • Coagulation
  • HELLP syndrome
  • Hemolysis
  • Liver
  • Platelets
  • Thrombophilia

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Kenny, L. C., McCrae, K. R., & Gary Cunningham, F. (2014). Platelets, coagulation, and the liver. In Chesley's Hypertensive Disorders in Pregnancy, Fourth Edition (pp. 379-396). Elsevier Science. https://doi.org/10.1016/B978-0-12-407866-6.00017-1

Platelets, coagulation, and the liver. / Kenny, Louise C.; McCrae, Keith R.; Gary Cunningham, F.

Chesley's Hypertensive Disorders in Pregnancy, Fourth Edition. Elsevier Science, 2014. p. 379-396.

Research output: Chapter in Book/Report/Conference proceedingChapter

Kenny, LC, McCrae, KR & Gary Cunningham, F 2014, Platelets, coagulation, and the liver. in Chesley's Hypertensive Disorders in Pregnancy, Fourth Edition. Elsevier Science, pp. 379-396. https://doi.org/10.1016/B978-0-12-407866-6.00017-1
Kenny LC, McCrae KR, Gary Cunningham F. Platelets, coagulation, and the liver. In Chesley's Hypertensive Disorders in Pregnancy, Fourth Edition. Elsevier Science. 2014. p. 379-396 https://doi.org/10.1016/B978-0-12-407866-6.00017-1
Kenny, Louise C. ; McCrae, Keith R. ; Gary Cunningham, F. / Platelets, coagulation, and the liver. Chesley's Hypertensive Disorders in Pregnancy, Fourth Edition. Elsevier Science, 2014. pp. 379-396
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