Pneumocystis carinii pneumonia in patients with diamond-blackfan anemia receiving high-dose corticosteroids

Winston W. Huh; Joan Gill; Sujit Sheth; George R. Buchanan

doi:10.1097/00043426-200206000-00018

Pneumocystis carinii pneumonia in patients with diamond-blackfan anemia receiving high-dose corticosteroids

Winston W. Huh, Joan Gill, Sujit Sheth, George R. Buchanan

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

The authors describe three infants with Diamond-Blackfan anemia receiving corticosteroids who were diagnosed with Pneumocystis carinii pneumonia. Two patients exhibited intermittent neutropenia as well. Each child had been receiving relatively high doses of corticosteroids for at least 2 months, and two were having prednisone tapered when pneumonia developed. One child responded to trimethoprim/sulfamethoxazole and pentamidine, but the other two patients died. Infants with Diamond-Blackfan anemia receiving prolonged corticosteroid therapy should receive P. carinii pneumonia prophylaxis, such as trimethoprim/sulfamethoxazole, and prophylaxis should continue during corticosteroid tapering.

Original language	English (US)
Pages (from-to)	410-412
Number of pages	3
Journal	Journal of Pediatric Hematology/Oncology
Volume	24
Issue number	5
DOIs	https://doi.org/10.1097/00043426-200206000-00018
State	Published - 2002

Keywords

Anemia
Corticosteroids
Diamond-Blackfan
Pneumocystis carinii

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Hematology
Oncology

Access to Document

10.1097/00043426-200206000-00018

Cite this

@article{bee65c9a9b5243b4a1b0a62e24c2bf88,

title = "Pneumocystis carinii pneumonia in patients with diamond-blackfan anemia receiving high-dose corticosteroids",

abstract = "The authors describe three infants with Diamond-Blackfan anemia receiving corticosteroids who were diagnosed with Pneumocystis carinii pneumonia. Two patients exhibited intermittent neutropenia as well. Each child had been receiving relatively high doses of corticosteroids for at least 2 months, and two were having prednisone tapered when pneumonia developed. One child responded to trimethoprim/sulfamethoxazole and pentamidine, but the other two patients died. Infants with Diamond-Blackfan anemia receiving prolonged corticosteroid therapy should receive P. carinii pneumonia prophylaxis, such as trimethoprim/sulfamethoxazole, and prophylaxis should continue during corticosteroid tapering.",

keywords = "Anemia, Corticosteroids, Diamond-Blackfan, Pneumocystis carinii",

author = "Huh, {Winston W.} and Joan Gill and Sujit Sheth and Buchanan, {George R.}",

year = "2002",

doi = "10.1097/00043426-200206000-00018",

language = "English (US)",

volume = "24",

pages = "410--412",

journal = "Journal of Pediatric Hematology/Oncology",

issn = "1077-4114",

publisher = "Lippincott Williams and Wilkins",

number = "5",

}

TY - JOUR

T1 - Pneumocystis carinii pneumonia in patients with diamond-blackfan anemia receiving high-dose corticosteroids

AU - Huh, Winston W.

AU - Gill, Joan

AU - Sheth, Sujit

AU - Buchanan, George R.

PY - 2002

Y1 - 2002

N2 - The authors describe three infants with Diamond-Blackfan anemia receiving corticosteroids who were diagnosed with Pneumocystis carinii pneumonia. Two patients exhibited intermittent neutropenia as well. Each child had been receiving relatively high doses of corticosteroids for at least 2 months, and two were having prednisone tapered when pneumonia developed. One child responded to trimethoprim/sulfamethoxazole and pentamidine, but the other two patients died. Infants with Diamond-Blackfan anemia receiving prolonged corticosteroid therapy should receive P. carinii pneumonia prophylaxis, such as trimethoprim/sulfamethoxazole, and prophylaxis should continue during corticosteroid tapering.

AB - The authors describe three infants with Diamond-Blackfan anemia receiving corticosteroids who were diagnosed with Pneumocystis carinii pneumonia. Two patients exhibited intermittent neutropenia as well. Each child had been receiving relatively high doses of corticosteroids for at least 2 months, and two were having prednisone tapered when pneumonia developed. One child responded to trimethoprim/sulfamethoxazole and pentamidine, but the other two patients died. Infants with Diamond-Blackfan anemia receiving prolonged corticosteroid therapy should receive P. carinii pneumonia prophylaxis, such as trimethoprim/sulfamethoxazole, and prophylaxis should continue during corticosteroid tapering.

KW - Anemia

KW - Corticosteroids

KW - Diamond-Blackfan

KW - Pneumocystis carinii

UR - http://www.scopus.com/inward/record.url?scp=0036061986&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036061986&partnerID=8YFLogxK

U2 - 10.1097/00043426-200206000-00018

DO - 10.1097/00043426-200206000-00018

M3 - Article

C2 - 12142794

AN - SCOPUS:0036061986

SN - 1077-4114

VL - 24

SP - 410

EP - 412

JO - Journal of Pediatric Hematology/Oncology

JF - Journal of Pediatric Hematology/Oncology

IS - 5

ER -

Pneumocystis carinii pneumonia in patients with diamond-blackfan anemia receiving high-dose corticosteroids

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this